2010 Fiscal Year Final Research Report
Molecular-targ eted therapy for refractory immune-mediated neuropat hies
| Project/Area Number |
21790839
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Nagoya University |
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Principal Investigator |
IIJIMA Masahiro Nagoya University, 医学系研究科, COE特任助教 (40437041)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 免疫性ニューロパチー / 難治性ニューロパチー / rituximab / 新規治療薬 / 多巣性運動ニューロパチー / CIDP / 抗MAG抗体陽性IgM-MGUSニューロパチー |
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| Research Abstract |
In this study, we demonstrated the effect and safety of rituximab for various refractory immune-mediated neuropathies. Rituximab (375 mg/m^2 intravenously each week for 4 weeks) was administered in an openlabel design to one patient with multifocal motor neuropathy (MMN), one with chronic inflammatory demyelinating polyneuropathy (CIDP), one with neuropathy associated with Sjogren's syndrome (SN), and four with anti-MAG IgM-MGUS neuropathy (IgM-N). Reduction of total IVIg requirements of a patient with MMN, although the effect was only temporary, were suggested to be responded to rituximab. Improvement of clinical status in three patients with IgM-N suggeted that rituximab was well tolerated and is a promising new drug. No adverse events occurred in all patients.
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[Journal Article] Systemic but asymptomatic transthyretin amyloidosis 8 years after domino liver transplantation.2010
Author(s)
Koike H, Kiuchi T, Iijima M, Ueda M, Ando Y, Morozumi S, Tomita M, Kawagashira Y, Watanabe H, Katsuno M, Shimoyama Y, Okazaki Y, Kamei H, Sobue G
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Journal Title
J Neurol Neurosurg Psychiatry. (Epub ahead of print)
Peer Reviewed
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[Journal Article] Clinicopathological features of acute autonomic and sensory neuropathy.2010
Author(s)
Koike H, Atsuta N, Adachi H, Iijima M, Katsuno M, Yasuda T, Fukada Y, Yasui K, Nakashima K, Horiuchi M, Shiomi K, Fukui K, Takashima S, Morita Y, Kuniyoshi K, Hasegawa Y, Toribe Y, Kajiura M, Takeshita S, Mukai E, Sobue G
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Journal Title
Brain. 133
Pages: 2881-2896
Peer Reviewed
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[Journal Article] Pyramidal tract involvement in Guillain-Barre syndrome associated with anti-GM1 antibody.2010
Author(s)
Tomita M, Watanabe H, Morozumi S, Kawagashira Y, Iijima M, Nakamura T, Katsuno M, Koike H, Hattori N, Hirayama M, Kusunoki S, Sobue G
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Journal Title
J Neurol Neurosurg Psychiatry. 81
Pages: 583-585
Peer Reviewed
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