2010 Fiscal Year Final Research Report
The investigation of the pathophysiological effects of ghrelin in diabetic neuropathy.
| Project/Area Number |
21790877
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | University of Miyazaki |
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Principal Investigator |
SHIIYA Tomomi University of Miyazaki, 医学部, 助教 (50524196)
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| Project Period (FY) |
2009 – 2010
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| Keywords | グレリン / 糖尿病 / 糖尿病性神経障害 / 自律神経障害 |
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| Research Abstract |
We investigated the effects of ghrelin for glucose metabolism in both healthy and diabetic subjects. After overnight fasting, human synthetic ghrelin (0.5 μg/kg) or saline were intravenously administered to 11 type 2 diabetic patients without complications and age-, sex-, and BMI-matched 6 healthy subjects immediately before a liquid meal. Plasma glucose and insulin levels and appetite were similar in the administration of saline or ghrelin in both healthy subjects and diabetic patients. Plasma GH, ghrelin, des-acyl ghrelin levels were significantly increased in ghrelin administration than saline, but they returned to basal levels at 90 min after the administration. Six type 2 diabetic patients with neuropathy were administered 1.0 μg/kg ghrelin once a day for two weeks after breakfast. Ghrelin did not change their food intake nor body weight, however, increased lean body mass and reduced fat mass. The subjective symptoms and the nerve conduction verosity of post tibial nerves were improved in all patients. Two weeks ghrelin administration improved glucose and lipid metabolism. Thus, ghrelin may be a novel treatment for diabetic neuropathy.
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Research Products
(6 results)
