2010 Fiscal Year Final Research Report
Evaluation of the pathophysiological significance of peripheral clocks and the development of methods of controlling them
| Project/Area Number |
21790880
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
ANDO Hitoshi Jichi Medical University, 医学部, 准教授 (50382875)
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| Project Period (FY) |
2009 – 2010
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| Keywords | メタボリックシンドローム / 体内時計 / 時計遺伝子 / 2型糖尿病 |
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| Research Abstract |
To elucidate the physiological significance and controlling mechanism of peripheral clocks, the biological clocks in obese diabetic ob/ob mice were studied. The impairment of circadian clocks in ob/ob mice was (1) found in the peripheral tissues, but not in the suprachiasmatic nucleus (central clock), (2) detectable before the development of metabolic abnormalities, and (3) improved by short-term treatment with leptin. These results suggest that the impairment of peripheral clocks is not a result of metabolic derangement and that leptin signaling is important for maintaining the peripheral clock functions.
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