2010 Fiscal Year Final Research Report
Analysis of the role of ETV6/FLT3 in oncogenesis, using a murine bone marrow transduction model
| Project/Area Number |
21790913
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
HISHIZAWA Masakatsu Kyoto University, 大学院・医学研究科, 助教 (90444455)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 血液腫瘍学 |
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| Research Abstract |
We identified a novel ETV6/FLT3 variant fusion transcript in myeloproliferative disease (MPD) with T-lymphoblastic leukemia/lymphoma (T-LBL). To investigate the role of ETV6/FLT3 fusion gene in oncogenesis, we used a murine bone marrow transplant model. ETV6/FLT3 induced a rapidly fatal MPD in primary recipient mice. We demonstrated that the Grb2-Gab2 pathway plays an important role in oncogenesis.
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