2010 Fiscal Year Final Research Report
Analysis of ectopic expression of autoantigen genes using Aire+ cell lines
| Project/Area Number |
21790952
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
YAMAGUCHI Yoshitaka Keio University, 先導研究センター, 助教 (50365433)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 胸腺 / 免疫学的寛容 / 自己免疫疾患 / AIRE / 末梢組織特異的遺伝子 |
|---|
| Research Abstract |
Autoimmune polyendocryne syndrome type 1 (APS1, called also APECED) is caused by mutations in AIRE (Autoimmune Regulator) gene. We used our established Aire-expressing cell lines for following up AIRE functions and aimed for elucidation of the pathogenic mechanism and establishment of therapy for autoimmune diseases. In this study, we found that gene expression level of Aire, various self-antigens and subunits of proteasomes that process the antigens varies depending on conditions of Aire-expressing cells.
|
