2010 Fiscal Year Final Research Report
The roles for chemokines in induction and maintenance of humoral immunity or cell-mediated immunity
| Project/Area Number |
21790963
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Toho University |
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Principal Investigator |
TANAKA Yuriko Toho University, 医学部, 助教 (40396685)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ケモカイン / 細胞性免疫 / 体液性免疫 |
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| Research Abstract |
The roles for chemokines CCL19 and CCL21 in induction of humoral immunity or cell-mediated immunity were investigated using plt mutant mice, which lack expression of CCL19 and CCL21-ser in their lymphoid organs. When the mice were immunized with ovalbumin(OVA) in adjuvant, the amount of anti-OVA IgG in serum was higher in plt mice as compared to BALB/c WT mice. However, the antigen specific CTL induction inhibited in plt mice. These findings indicate that CCL19 and CCL21 induce prompt antibody responses to antigen, and regulate T cell responses in vivo.
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