2010 Fiscal Year Final Research Report
Exploration of disease-specific biomarker in systemic juvenile idiopathic arthritis.
| Project/Area Number |
21791002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
AOYAMA Michiko Kyoto Prefectural University of Medicine, 医学研究科, 助教 (40363981)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 全身型若年性特発性関節炎 / プロテオミクス / ネイティブPAGE |
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| Research Abstract |
Diagnostic biomarker in systemic juvenile arthritis (sJIA) remains to be elucidated. An exploration of disease-specific marker in sJIA was conducted with a native PAGE-combined 2-DE. Peptide mapping with sera form 4 sJIA patients revealed several spots such as iron-related proteins, lipoproteins, complements, globulin-related molecules, which were similar in profiling pattern to the control samples from febrile patients. Haptoglobin 2-2 genotype was uniformaly detected in sJIA sera. A unique transthyretin-combined protein complex was also profiled in sJIA sera. These results might be a breakthrough in establishing sJIA-specific biomarker.
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