• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Exploration of disease-specific biomarker in systemic juvenile idiopathic arthritis.

Research Project

  • PDF
Project/Area Number 21791002
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

AOYAMA Michiko  Kyoto Prefectural University of Medicine, 医学研究科, 助教 (40363981)

Project Period (FY) 2009 – 2010
Keywords全身型若年性特発性関節炎 / プロテオミクス / ネイティブPAGE
Research Abstract

Diagnostic biomarker in systemic juvenile arthritis (sJIA) remains to be elucidated. An exploration of disease-specific marker in sJIA was conducted with a native PAGE-combined 2-DE. Peptide mapping with sera form 4 sJIA patients revealed several spots such as iron-related proteins, lipoproteins, complements, globulin-related molecules, which were similar in profiling pattern to the control samples from febrile patients. Haptoglobin 2-2 genotype was uniformaly detected in sJIA sera. A unique transthyretin-combined protein complex was also profiled in sJIA sera. These results might be a breakthrough in establishing sJIA-specific biomarker.

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi