2010 Fiscal Year Final Research Report
Investments of regenerative medicine for epidermolysis bullosa using bone marrow stem cells
Project/Area Number |
21791052
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Dermatology
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Research Institution | Hokkaido University |
Principal Investigator |
INOKUMA Daisuke Hokkaido University, 大学院・医学研究科, 助教 (30443956)
|
Project Period (FY) |
2009 – 2010
|
Keywords | 皮膚炎症 / 再生学 |
Research Abstract |
Recent studies have suggested that bone marrow cells transdifferentiate to a variety of cellular lineages including skin. Investments to achieve radical cure for congenital disorder, to which there is no effective therapy, have been done. In our study, first as a basic research step, we demonstrated the existence of the factors secreted from keratinocytes that induces transdifferentiation from bone marrow derived cells into keratinocyte. Next as a preclinical step, bone marrow transplantation from normal mouse to type XVII collagen knock out mouse, one of the epidermolysis bullosa model mouse, induced production of the defect protein (XVII type collagen) and improvement of clinical manifestation of the mouse. So we suggested that the bone marrow transplantation from normal mouse to model mouse can be one of the effective therapies for epidermolysis bullosa.
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Research Products
(17 results)