2010 Fiscal Year Final Research Report
The role of SDF-1/CXCR4 signaling pathway on normal human keratinocyte
| Project/Area Number |
21791079
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Ehime University |
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Principal Investigator |
MIYAWAKI Saori Ehime University, 医学部附属病院, 医員 (90467853)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 皮膚生理学 |
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| Research Abstract |
Recentry, several groups reported the expression of stromal cell-derived factor1(SDF-1 ; CXCL12) express on human skin. However, the biological meanings is still unkown. We found that SDF-1 induces keratinocyte migration in a dose dependent manner through EGF receptor via ERK(p42/44) activation.
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