2010 Fiscal Year Final Research Report
Analysis of platelets and cell adhesion molecules as therapeutic targets in the immune-complex diseases
Project/Area Number |
21791081
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Dermatology
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Research Institution | Nagasaki University |
Principal Investigator |
HARA Toshihide Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (90380956)
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Project Period (FY) |
2009 – 2010
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Keywords | 炎症 / 免疫複合体病 / 血小板 / 細胞接着分子 / アルサス反応 |
Research Abstract |
To assess the role of platelets in the immune-complex diseases, the cutaneous Arthus reaction was examined in wild type mice and mice lacking E-selectin, P-selectin, or P-selectin glycoprotein ligand-1 (PSGL-1) with or without platelet depletion by busulfan. Edema and hemorrhage induced by immune complex challenge significantly decreased in busulfan-treated wild type mice compared with untreated mice. Busulfan treatment did not affect edema and hemorrhage in P-selectin- or PSGL-1-deficient mice, suggesting that the effect by busulfan is dependent on P-selectin and PSGL-1 expression. These results suggest that platelets induce leukocyte recruitment into skin by forming platelet-leukocyte aggregates and secreting chemokines at inflamed sites.
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Research Products
(3 results)
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[Journal Article] Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction.2009
Author(s)
Hara T, Shimizu K, Ogawa F, Yanaba K, Iwata Y, Muroi E, Takenaka M, Komura K, Hasegawa M, Fujimoto M, Sato S
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Journal Title
Am J Pathol.2010Jan 176(1)(Epub)
Pages: 259-269
Peer Reviewed
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