Diagnosis procedure for narcolepsy using urine orexin measurement

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791108
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Akita University
• Principal Investigator: TAKEMURA Fumi Akita University, 大学院・医学系研究科, 助教 (40508280)
• Project Period (FY): 2009 – 2010
• Keywords: 精神生理学 / 過眠症 / ナルコレプシー / オレキシン / 血中・尿中濃度

Research Abstract

For the diagnosis of narcolepsy, CSF orexin measurement is performed. However, the lumber puncture to obtain CSF is invasive procedure for many patients. It would be great benefit for them that orexin from plasma or unine could be measured for diagnosis. We tried the measurement for orexin from urine (extraction from 50ml) and plasma (10-20 times higher amount of sample dose). We could get some results by these procedure, however, the data seemed not to be real orexin levels. It would be the results of measurements for other similar substances. Further experimental study should be needed using higher sensitive antibody for orexin.

Research Products

• [Journal Article] The pathophysiologic basis of secondary narcolepsy and hypersomnia. (2011)
  • Author(s): Kanbayashi T, Sagawa Y, Takemura F, Ito SU, Tsutsui K, Hishikawa Y, Nishino S.
  • Journal Title: Curr Neurol Neurosci Rep. 11(2) Pages: 235-241
  • Peer Reviewed
• [Journal Article] CSF meranin-concentrating hormone concentrarion in norcolepsy and various neurological disorders. (2010)
  • Author(s): Kanbayashi T., Ito W., Takemura T., Takemura F., Takahashi S., Sato M., Hayashi Y., Sagawa Y., Nishino S., Shimizu T.
  • Journal Title: SLEEP Volume 33, Abstract Supplement Pages: A284
  • Peer Reviewed
• [Journal Article] 終夜睡眠ポリグラフ検査にて脳波異常が確認され、確定診断となったてんかんの一例(会議録/症例報告) (2010)
  • Author(s): 佐藤雅俊, 徳永純, 武村史, 筒井幸, 伊東若子, 神林崇, 清水徹男
  • Journal Title: 精神神経学雑誌 (0033-2658)2010特別 Pages: S-352
• [Journal Article] リタリン処方制限に伴い当院へ紹介となったナルコレプシー疑い患者の最終診断 (2009)
  • Author(s): 徳永純、佐藤雅俊、佐川洋平、武村史、武村尊生、兼子義彦、林由里子、神林崇、清水徹男
  • Journal Title: 精神神経学雑誌 (0033-2658)111巻6号 Pages: 708
• [Journal Article] 【高齢者の睡眠障害】高齢者の睡眠障害の診断と治療導入(解説/特集) (2009)
  • Author(s): 武村尊生, 武村史, 神林崇, 清水徹男
  • Journal Title: 睡眠医療 (1882-2096)3巻2号 Pages: 183-190
• [Presentation] ナルコレプシーと様々な神経疾患におけるCSF中のmelanin-concentrating hormone (MCH)の測定 (2010)
  • Author(s): 神林崇, 伊東若子, 武村尊生, 武村史, 林由理子, 丸山史, 佐川洋平, 相澤里香, 西野精治, 清水徹男
  • Organizer: 日本睡眠学会第35回定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20100700
• [Presentation] 蓄積した睡眠不足によりMSLTにて偽陽性となる症例の検討 (2010)
  • Author(s): 木澤哲也, 松淵浪子, 細川敬輔, 徳永純, 伊東若子, 佐藤雅俊, 田ヶ谷浩邦, 武村尊生, 武村史, 神林崇, 清水徹男
  • Organizer: 日本睡眠学会第35回定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20100700
• [Presentation] 過眠症患者のCSFオレキシンの「中間値」は何を意味するか? (2009)
  • Author(s): 武村尊生、神林崇、近藤英明、佐川洋平、武村史、鈴木稔、大沼俊、林由理子、筒井幸、徳永純、菊池結花、佐藤雅俊、清水徹男
  • Organizer: ASRS The 6th Congress of Asian Sleep Research Society, JSSR The 34th Annual Meeting of Japanese Society of Sleep Research, JSC The 16th Annual Meeting of Japanese Society for Chronobiology 2009, Joint Congress
  • Place of Presentation: Osaka
  • Year and Date: 20091024-20091027
• [Presentation] WHAT DOES THE INTERMEDIATE VALUE OF CSF OREXIN IN HYPRSOMNIA PATIENTS SUGGEST? SLEEP 2009 (2009)
  • Author(s): Takemura T, Kanbayashi T, Takemura F, Kikuhci Y, Shimizu T, et al.
  • Organizer: A247-248 23rd Annual Meeting of the Associated Professional Sleep Societies.Seattle
  • Place of Presentation: Washington
  • Year and Date: 20090600
• [Presentation] SYMPTOMATIC NARCOLEPSY IN MS AND NMO PATIENTS. SLEEP 2009 (2009)
  • Author(s): Kanbayashi T, Nakashima I, Shimohata T, Nakamura M, Oka Y, Takemura T, Takemura F, Iijima S, Shimizu T, Nishino S
  • Organizer: A247 23rd Annual Meeting of the Associated Professional Sleep Societies.Seattle
  • Place of Presentation: Washington
  • Year and Date: 20090600
• [Remarks] ホームページ等