2010 Fiscal Year Final Research Report
Examination for effects of Dimorphism on the response to modafinil and methylphenidate
| Project/Area Number |
21791109
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Akita University |
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Principal Investigator |
KIKUCHI Yuka 秋田大学, 医学部, 助教 (20534093)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ナルコレプシー / モダフィニル / メチルフェニデート / 遺伝子多型 / 血中濃度 |
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| Research Abstract |
Since, Dauvillriers et al. (2002) reported that a sexual dimorphism in COMT activity affects the response to modafinil (first line medication), we planned to re-examine it in the Japanese population. In addition, we also examined methlphenidate, which is a second line medication. We examined gene polymorphism of COMT(158 Val/Met), orexin2 receptor (1246G>A), clock gene (3111 T>C) and BDNF (66 val/met) in about 50 subjects with narcolepsy or idiopathic hypersomnia. It is reported that narcolepsy presents tight associations with a specific HLA genes (DQB1*0602, DRB1*1501), so these genes were also tested. As for orexin2 receptor (1246G>A), 87.5% were G/G and 12.5% were G/A. As for clock gene (3111 T>C), 31.2% were T/C and 68.7% were T/T. As for COMT(158 Val/Met), 68.7% were Val/Met, 28.1% were Val/Val and 3.1% were Met/Met. As for BDNF (66val/met), 71.9% were Val/Met, 15.6% were Val/Val and 12.5% were Met/Met. As for HLA typing, 95% patients with narcolepsy-cataplexy had HLA-DRB1*1501 and DQB1*0602. Considering about the HLA typing and medications, majority of subjects who have DRB1*0901 were treated with methylphenidate (p<0.05). Majority of subjects who have DQB1*0301 were treated with modafinil (p<0.05). Majority of subjects who have DQB1*0303 were treated with methylphenidate (p<0.05). In regard to COMT polymorphism, there were no significant effects on the diagnosis, medications and HLA typing.
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[Journal Article] A case with hypocretin (orexin) deficient narcolepsy, Parkinson's disease and severe psychosis was successfully treated by modified electro-convulsive therapy2011
Author(s)
Yuya Takahashi, Yuka Kikuchi, Takashi Kanbayashi, Hanazono Akira, Shunichiro Abe, Shinobu Iwaki, Ko Tsutsui, Hideka Suda, Fumi Maruyama, Tetsuo Shimizu
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Journal Title
Akita J Med
Volume: 38巻2号
Pages: 81-84
Peer Reviewed
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[Presentation] 精神症状を認め抗NMDAR抗体陽性のナルコレプシーの2例2010
Author(s)
細川敬輔, 細川里絵, 木澤哲也, 伊東若子, 徳永純, 岩城忍, 佐川洋平, 菊池結花, 丸山史, 松渕浪子, 田中惠子, 神林崇, 清水徹男
Organizer
日本睡眠学会第35回定期学術集会
Place of Presentation
名古屋国際会議場イベントホール
Year and Date
2010-07-01
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[Presentation] EVALUATION OF CSF HISTAMINE IN THE PATIENTS WITH NARCOLEPSY OR VARIOUS DISEASES2010
Author(s)
Ito W, Kanbayashi T, Kodama T, Kikuchi Y, Arii J, Shimizu K, Aizawa R, Chiba S, Yano T, Shimizu T
Organizer
Annual Meeting of the Associated Professional Sleep Societies
Place of Presentation
San Antonio, TX, USA
Year and Date
2010-06-07
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[Presentation] THE EVALUATION OF PHYSICAL AND COGNITIVE FUNCTIONS, AROUSAL LEVELS AND MOODS IN HEALTHY UNIVERSITY STUDENTS AFTER ZALEPLON ADMINISTRATION2010
Author(s)
Ito W, Shimizu K, Ito SU, Wakasa M, Narita E, Suda H, Kikuchi Y, Tsutsui K, Kanbayashi T, Shimizu T
Organizer
Annual Meeting of the Associated Professional Sleep Societies
Place of Presentation
San Antonio, TX, USA
Year and Date
2010-06-07
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