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2012 Fiscal Year Final Research Report

A research of aberrant brain volume and function and biological marker in patients with autism spectrum disorders.

Research Project

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Project/Area Number 21791120
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionUniversity of Fukui

Principal Investigator

KOSAKA Hirotaka  福井大学, 子どものこころの発達研究センター, 特命准教授 (70401966)

Project Period (FY) 2009 – 2012
Keywords児童・思春期精神医学 / 自閉症スペクトラム障害 / voxel based morphometry (VBM) / functional MRI (fMRI) / オキシトシン / 社会性の障害 / 右島 / 右下前頭回
Research Abstract

Much evidence indicates that patients with autism spectrum disorders (ASD) demonstrate marked social dysfunction. However,the etiology is still unknown. We have studied social dysfunctions in youth with high-functioning ASD compared with typically developing participants using voxel-based morphometry and functional MRI. These aberrant neuroimaging findings could be social brain marker in ASD. Next, I reported oxytocin effect to a patient with ASD

  • Research Products

    (29 results)

All 2013 2012 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (20 results)

  • [Journal Article] 自閉症スペクトラム障害のfMRI研究2013

    • Author(s)
      小坂浩隆、等
    • Journal Title

      脳

      Volume: 21 16(2) Pages: 45-51

  • [Journal Article] 自閉症スペクトラム障害の社会性障害を探る: fMRI 研究2013

    • Author(s)
      小坂浩隆、等
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 23(4) Pages: 255-61

    • Peer Reviewed
  • [Journal Article] Emotional responses associated with self-face processing in individuals with autism spectrum disorders: An fMRI study2012

    • Author(s)
      Morita T, Kosaka H, et al.
    • Journal Title

      Social Neuroscience

      Volume: 7(3-4) Pages: 223-239

    • Peer Reviewed
  • [Journal Article] Long-term oxytocin administration improves social behaviors in a girl with autistic disorder.2012

    • Author(s)
      Kosaka H, et al.
    • Journal Title

      BMC Psychiatry

      Volume: 12(1) Pages: 110

    • Peer Reviewed
  • [Journal Article] Hard to "tune in": neural mechanisms of live face-to-face interaction in individuals with high-functioning autistic spectrum disorder.2012

    • Author(s)
      Tanabe HC, Kosaka H, et al.
    • Journal Title

      Front Hum Neurosci

      Volume: 6 Pages: 268

    • Peer Reviewed
  • [Journal Article] Differential amygdala response to lower face in patients with autistic spectrum disorders: an fMRI study2011

    • Author(s)
      Ishitobi M, Kosaka H, et al.
    • Journal Title

      Research in Autism Spectrum Disorders

      Volume: 5 Pages: 910-9

    • Peer Reviewed
  • [Journal Article] Smaller Insula and Inferior Frontal Volumes in Young Adults with Pervasive Developmental Disorders2010

    • Author(s)
      Kosaka H, et al.
    • Journal Title

      Neuroimage.

      Volume: 50(4) Pages: 1357-1363

    • Peer Reviewed
  • [Journal Article] "Stay tuned": Inter-individual neural synchronization during mutual gaze and joint attention2010

    • Author(s)
      Saito DN, et al.,
    • Journal Title

      Frontiers in Integrative Neuroscience

      Volume: 4 Pages: 127

    • Peer Reviewed
  • [Journal Article] 青年期広汎性発達障害者の脳灰白質減少-VBM研究-2009

    • Author(s)
      小坂浩隆、等
    • Journal Title

      臨床脳波

      Volume: 51(8) Pages: 483-489

    • Peer Reviewed
  • [Presentation] Functional MRI researches in patients with autism spectrum disorders2013

    • Author(s)
      Kosaka H
    • Organizer
      Scientifoc Forum for Autism Spectrum Disorder
    • Place of Presentation
      Ishikawa, Japan, シンポジウム
    • Year and Date
      2013-02-16
  • [Presentation] Social behaviors of autistic disorder are improved by long-term oxytocin administration: a case of 16-year-old girl2012

    • Author(s)
      Kosaka H, et al
    • Organizer
      The 42th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      New Orleans, USA, ポスター
    • Year and Date
      2012-10-14
  • [Presentation] Neuroimaging and Oxytocin effect in Youth with Autism Spectrum Disorders2012

    • Author(s)
      Kosaka H.
    • Organizer
      The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry / The 55th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Japan, シンポジウム
    • Year and Date
      2012-10-01
  • [Presentation] 「社会脳科学:領域を超えた融合と発展」自閉症スペクトラム障害の社会性障害を探る: fMRI研究2012

    • Author(s)
      小坂浩隆
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸、シンポジウム
    • Year and Date
      2012-09-29
  • [Presentation] 自閉症スペクトラム障害の顔認知と対人同調の不全: fMRI研究2012

    • Author(s)
      小坂浩隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      愛知、シンポジウム
    • Year and Date
      2012-09-20
  • [Presentation] Is it easy for autistic people to think about an autistic character's behavior in a story? The effect of similarity between readers and characters in recognition2012

    • Author(s)
      Komeda H, Kosaka H, et al
    • Organizer
      The 22nd Annual Meeting of the Society for Text & Discourse
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2012-07-10
  • [Presentation] Self-Related Representation in Individuals with High-Functioning Autism2012

    • Author(s)
      Komeda H, Kosaka H, et al
    • Organizer
      The 10th International Meeting for Autism Research (IMFAR)
    • Place of Presentation
      Toronto, Canada, ポスター
    • Year and Date
      2012-05-17
  • [Presentation] 青年期自閉症スペクトラム障害の脳研究2012

    • Author(s)
      小坂浩隆
    • Organizer
      第7回統合失調症学会学術集会
    • Place of Presentation
      名古屋、愛知、シンポジウム
    • Year and Date
      2012-03-16
  • [Presentation] Oxytocin effect in young males with autism spectrum disorders: Aneye-tracking study2011

    • Author(s)
      Kosaka H, et al.
    • Organizer
      Exploring Autism Research Collaboration Between Japan and United States Joint Academic Conference on Autism Spectrum Disorders
    • Place of Presentation
      Tokyo, Japan, ポスター
    • Year and Date
      2011-12-02
  • [Presentation] Oxytocin facilitates eye contact in young males with autism spectrum disorders2011

    • Author(s)
      Kosaka H, et al
    • Organizer
      The 41th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA, ポスター
    • Year and Date
      2011-11-12
  • [Presentation] 自閉症スペクトラムにおけるExtrastriate body area (EBA) の機能低下-相互模倣時の自他の動作の比較にかかわる神経基盤2011

    • Author(s)
      岡本悠子、小坂浩隆、等
    • Organizer
      第34回日本神経科学大会-こころの脳科学-
    • Place of Presentation
      神奈川
    • Year and Date
      2011-09-14
  • [Presentation] 高機能自閉症スペクトラム成人の物語読解2011

    • Author(s)
      米田英嗣、小坂浩隆、等
    • Organizer
      第10回日本自閉症スペクトラム学会
    • Place of Presentation
      愛知
    • Year and Date
      2011-09-11
  • [Presentation] 自閉症スペクトラムにおけるEBAの機能低下-相互模倣時の自他の動作の比較に関わる神経基盤2011

    • Author(s)
      岡本悠子、小坂浩隆、等
    • Organizer
      第13回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-01
  • [Presentation] Neural substrates of joint attention and inter-individual functional connectivity during mutual gaze in individuals with normal and autism spectrum disorders using dual functional MRI.2011

    • Author(s)
      Tanabe HC, Kosaka H, et al
    • Organizer
      The 17th annual meeting of the Organization for Human Brain Mapping (OHBM)
    • Place of Presentation
      Quebec, Canada, ポスター
    • Year and Date
      2011-06-26
  • [Presentation] 広汎性発達障害における自己評価プロセス:fMRI研究2010

    • Author(s)
      守田知代、小坂浩隆、等
    • Organizer
      Nuero 2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
  • [Presentation] Correlations Between Smaller Brain Volume and Autism Spectrum Quotient or Intelligence Quotient in Young Male Adults with Pervasive Developmental Disorders2010

    • Author(s)
      Kosaka H, et al
    • Organizer
      The 4th International Workshop on Biomedical Imaging (Fukui 2010)
    • Place of Presentation
      Fukui, Japan、口演&ポスター
    • Year and Date
      2010-01-25
  • [Presentation] Cingulate cortex dysfunction during self-face evaluation in pervasive developmental disorders.Japan-US Brain Research Workshop2010

    • Author(s)
      Morita T, Kosaka H, et al
    • Organizer
      Development of social brain
    • Place of Presentation
      Development of social brain
    • Year and Date
      2010-01-23
  • [Presentation] Abnormal self-awareness in pervasive developmental disorders.2009

    • Author(s)
      Morita T, Kosaka H, et al.
    • Organizer
      International Symposium: New Frontiers in Social Cognitive Neuroscience
    • Place of Presentation
      Sendai, Miyagi, Japan
    • Year and Date
      2009-11-27
  • [Presentation] Decreased bilateral insulae volume in youth with pervasive developmental disorders2009

    • Author(s)
      Kosaka H, et al
    • Organizer
      2009 Asian and Oceanian Congress on Clinical Neurophysiology (AOCCN)
    • Place of Presentation
      Seoul, Korea, ポスター
    • Year and Date
      2009-04-16
  • [Presentation] Differential amygdala response to lower face in patients with pervasive developmental disorder: an fMRI study.2009

    • Author(s)
      Ishitobi M, Kosaka H, et al
    • Organizer
      2009 Asian and Oceanian Congress on Clinical Neurophysiology (AOCCN)
    • Place of Presentation
      Seoul, Korea, ポスター
    • Year and Date
      2009-04-16

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Published: 2014-08-29  

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