2010 Fiscal Year Final Research Report
Identification of suicidal-behavior related genes in the HPA axis regulating stress response
| Project/Area Number |
21791132
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
HISHIMOTO Akitoyo Kobe University, 大学院・医学研究科, 講師 (50529526)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 臨床精神分子遺伝学 |
|---|
| Research Abstract |
We explored a positive association of suicidal behavior with certain haplotypes of FKBP5 gene which regulates the hypothalamo-pituitary-adrenal axis in stress response. We additionally explored associations of suicidal behavior with polymorphisms of ALDH2 and NOS1 genes. We also found a positive association of schizophrenia with polymorphisms of NOS1 gene. Our findings suggest that suicidal behavior is involved in the genetic vulnerability and that certain polymorphisms might be useful for a biomarker of suicidal behavior.
|
