2011 Fiscal Year Final Research Report
Development of a molecular imaging probe for vulnerable plaque imaging
| Project/Area Number |
21791181
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
OGAWA Mikako 浜松医科大学, メディカルフォトニクス研究センター, 准教授 (20344351)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 動脈硬化 / 分子イメージング |
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| Research Abstract |
The rupture of atherosclerotic vulnerable plaques and the subsequent formation of thrombi are the main factors responsible for myocardial and cerebral infarctions. Macrophage infiltration is characteristics for atherosclerotic vulnerable plaques. Macrophages recognize phosphatidylserine(PS) that is exposed on the cell surface of the apoptotic cells to phagocytize these cells. In this study, we prepared PS liposomes for detection of vulnerable plaques. As a result, the atherosclerotic region was detected by this imaging probe.
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