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2010 Fiscal Year Final Research Report

Development of multi-functional radiosensitizer based on in vivo radiosensitizing activity using tumor-implant chick embryo

Research Project

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Project/Area Number 21791198
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionThe University of Tokushima

Principal Investigator

UTO Yoshihiro  The University of Tokushima, 大学院・ソシオテクノサイエンス研究部, 准教授 (20304553)

Project Period (FY) 2009 – 2010
Keywords発育鶏卵 / 放射線増感剤 / 固形腫瘍
Research Abstract

Chick embryo have been used as alternative experimental animals in various research fields, including virology, immunology, toxicology, oncology, and embryology. In this research, we developed the screening system of in vivo radiosensitizing activity of etanidazole as a radiosensitizer using tumor-bearing chick embryo. Moreover, we succeeded the evaluation of pharmacokinetic property of etanidazole using this model.

  • Research Products

    (27 results)

All 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (14 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo2011

    • Author(s)
      Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, Nakata E, Hori H
    • Journal Title

      J Radiat Res 52

      Pages: 208-214

    • Peer Reviewed
  • [Journal Article] Synthesis and photophysical properties of new SNARF derivatives as dual emission pH sensors2011

    • Author(s)
      Nakata E, Nazumi Y, Yukimachi Y, Uto Y, Maezawa H, Hashimoto T, Okamoto Y, Hori H
    • Journal Title

      Bioorg Med Chem Lett 21

      Pages: 1663-1666

    • Peer Reviewed
  • [Journal Article] Medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and invention of boron tracedrugs as innovative future-architectural drugs2010

    • Author(s)
      Hori H, Uto Y, Nakata E
    • Journal Title

      Anticancer Res 30

      Pages: 3233-3242

    • Peer Reviewed
  • [Journal Article] Vitamin D Binding Protein-Macrophage Activating Factor Inhibits HCC in SCID Mice2010

    • Author(s)
      Nonaka K, Onizuka S, Ishibashi H, Uto Y, Hori H, Nakayama T, Matsuura N, Kanematsu T, Fujioka H
    • Journal Title

      J Surg Res in press

    • Peer Reviewed
  • [Journal Article] A newly designed cell-permeable SNARF derivative as an effective intracellular pH indicator2010

    • Author(s)
      Nakata E, Yukimachi Y, Nazumi Y, Uto Y, Maezawa H, Hashimoto T, Okamoto Y, Hori H
    • Journal Title

      Chem Commun (Camb) 46

      Pages: 3526-3528

    • Peer Reviewed
  • [Journal Article] Design of novel hypoxia-targeting IDO hybrid inhibitors conjugated with an unsubstituted L-TRP as an IDO affinity moiety2010

    • Author(s)
      Nakashima H, Ikkyu K, Nakashima K, Sano K, Uto Y, Nakata E, Nagasawa H, Sugimoto H, Shiro Y, Nakagawa Y, Hori H
    • Journal Title

      Adv Exp Med Biol 662

      Pages: 415-421

    • Peer Reviewed
  • [Journal Article] Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging2009

    • Author(s)
      Nakata E, Yukimachi Y, Kariyazono H, Im S, Abe C, Uto Y, Maezawa H, Hashimoto T, Okamoto Y, Hori H
    • Journal Title

      Bioorg Med Chem 17

      Pages: 6952-6958

    • Peer Reviewed
  • [Journal Article] A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics"2009

    • Author(s)
      Uto Y, Koyama D, Otsuki M, Otomo N, Shirai T, Abe C, Nakata E, Nagasawa H, Hori H
    • Journal Title

      Adv Exp Med Biol 645

      Pages: 109-114

    • Peer Reviewed
  • [Journal Article] Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer2009

    • Author(s)
      Miyake K, Shimada M, Nishioka M, Sugimoto K, Batmunkh E, Uto Y, Nagasawa H, Hori H
    • Journal Title

      Cancer Chemother Pharmacol 64

      Pages: 885-892

    • Peer Reviewed
  • [Journal Article] Correlation between antiangiogenic activity and antioxidant activity of various components from propolis2009

    • Author(s)
      Ahn MR, Kunimasa K, Kumazawa S, Nakayama T, Kaji K, Uto Y, Hori H, Nagasawa H, Ohta T
    • Journal Title

      Mol Nutr Food Res 53

      Pages: 643-651

    • Peer Reviewed
  • [Journal Article] 次世代動物実験系としての腫瘍移植鶏卵の構築と放射線照射による腫瘍成長阻害活性2009

    • Author(s)
      安部千秋, 宇都義浩, 遠藤良夫, 新元優也, 中島宏一郎, 佐野圭一郎, 佐々木有紀, 皆巳和賢, 前澤博, 増永慎一郎, 中田栄司, 堀均
    • Journal Title

      放射線生物研究 44

      Pages: 233-241

  • [Presentation] In vivo antioxidative activity of radical-containing-nanoparticle (RNP) in fertilized chicken egg assay2011

    • Author(s)
      Uto Y, Abe C, Yoshitomi T, Nagasaki Y, Endo Y, Nakata E, Hori H
    • Organizer
      International Conference on Biomaterials Science 2011
    • Place of Presentation
      つくば市
    • Year and Date
      2011-03-16
  • [Presentation] 放射線増感活性における糖要求性からみたアセチル化グルコースハイブリッド放射線増感剤TX-2244のメディシナルケミストリー2011

    • Author(s)
      宇都義浩, 中江崇, 金園剛行, 村井絵美, 佐野圭一郎, 寺岡瑞絵, 富永正英, 前澤博, 堀均
    • Organizer
      第13回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良市
    • Year and Date
      2011-02-11
  • [Presentation] Systems biology-based drug design of sugar-hybrid hypoxic cell radiosensitizers using the tumor-implantable chick embryo model2010

    • Author(s)
      Uto Y, Abe C, Nakae T, Endo Y, Tominaga M, Maezawa H, Nakata E, Hori H
    • Organizer
      PACIFICHEM 2010
    • Place of Presentation
      ホノルル市
    • Year and Date
      2010-12-19
  • [Presentation] 癌免疫療法の確立を目指したマクロファージ活性化因子(GcMAF)前駆物質GcXの創製2010

    • Author(s)
      宇都義浩, 山本将太, 竹内亮太, 中川美典, 廣田慶司, 寺田弘, 鬼塚伸也, 中田栄司, 堀均
    • Organizer
      第14回バイオ治療法研究会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2010-12-11
  • [Presentation] SAR analysis of electron-rich polyyne analogues of FTY720 based on in vivo chick embryo antiangiogenic assay2010

    • Author(s)
      Uto Y, Abe C, Nakata E, Hori H
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-22
  • [Presentation] Prenylated acylphloroglucinol derivatives : Isoprenomics-based design, syntheses and antioxidative activities2010

    • Author(s)
      Uto Y, Tanaka R, Ohnaka K, Ohta Y, Yazaki K, Umemoto N, Nakata E, Hori H
    • Organizer
      International Society on Oxygen Transport to Tissue 2010
    • Place of Presentation
      アスコナ(スイス)
    • Year and Date
      2010-07-19
  • [Presentation] ストレス発育鶏卵モデルを用いたラジカル含有ナノ粒子TEMPO-RNPのin vivo抗酸化活性評価2010

    • Author(s)
      宇都義浩, 安部千秋, 吉冨徹, 長崎幸夫, 遠藤良夫, 中田栄司, 堀均
    • Organizer
      第63回日本酸化ストレス学会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-06-24
  • [Presentation] 腫瘍移植鶏卵モデルによる糖ハイブリッド放射線増感剤のin vivo放射線増感活性の評価2010

    • Author(s)
      宇都義浩, 安部千秋, 中江崇, 村井絵美, 遠藤良夫, 富永正英, 前澤博, 増永慎一郎, 中田栄司, 堀均
    • Organizer
      第16回国際癌治療増感研究会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-06-19
  • [Presentation] 抗酸化剤と酸化ストレスの新しい評価法2010

    • Author(s)
      宇都義浩
    • Organizer
      第7回学際物質戦略イニシアチブ バイオGPワークショップ
    • Place of Presentation
      つくば市
    • Year and Date
      2010-03-13
  • [Presentation] システムバイオロジー構築のためのフィチルキノールの合成と抗酸化活性評価2010

    • Author(s)
      宇都義浩, 山下洋平, 田中涼, 中田栄司, 堀均
    • Organizer
      第21回ビタミンE研究会
    • Place of Presentation
      東京都
    • Year and Date
      2010-01-22
  • [Presentation] 鶏胚異種移植腫瘍モデルを基盤とした糖ハイブリッド低酸素細胞放射線増感剤の創製2009

    • Author(s)
      中江崇, 宇都義浩, 安部千秋, 金園剛行, 新元優也, 佐野圭一郎, 中田栄司, 遠藤良夫, 富永正英, 前澤博, 橋本敏弘, 増永慎一郎, 堀均
    • Organizer
      創薬懇話会2009
    • Place of Presentation
      岐阜市
    • Year and Date
      2009-12-10
  • [Presentation] 腫瘍移植鶏卵を用いて薬物動態を考慮した糖ハイブリッド放射線増感剤のドラッグデザイン2009

    • Author(s)
      宇都義浩, 安部千秋, 遠藤良夫, 前澤博, 中田栄司, 堀均
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-01
  • [Presentation] 腫瘍移植鶏卵モデルによる糖ハイブリッド放射線増感剤の薬物動態解析2009

    • Author(s)
      宇都義浩, 中江崇, 安部千秋, 新元優也, 佐野圭一郎, 遠藤良夫, 富永正英, 前澤博, 中田栄司, 堀均
    • Organizer
      第15回国際癌治療増感研究会
    • Place of Presentation
      京都市
    • Year and Date
      2009-06-20
  • [Presentation] イソプレノミクスを基盤としたプレニル化フェニルプロパノイドの分子設計と発育鶏卵を用いたin ovo抗酸化活性の評価2009

    • Author(s)
      宇都義浩, 安部千秋, 山下洋平, 田中涼, 遠藤良夫, 中田栄司, 堀均
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-06-11
  • [Book] 酸素をターゲットとしたがんの治療 東京2009

    • Author(s)
      堀均, 宇都義浩, 永澤秀子, 中田栄司
    • Total Pages
      596(466-477)
    • Publisher
      朝倉書店
  • [Remarks] ホームページ等

    • URL

      http://www.bio.tokushima-u.ac.jp/a2group/a2index.html

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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