2010 Fiscal Year Final Research Report
Induction of HER2-specific cellular immunity after trastuzumab therapy
| Project/Area Number |
21791248
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Mie University |
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Principal Investigator |
SAITO Kanako Mie University, 医学部附属病院, 助教 (90447871)
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| Project Period (FY) |
2009 – 2010
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| Keywords | HER2 / トラスツズマブ / CTL |
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| Research Abstract |
We have investigated whether HER2-specific cellular immunity could be induced after trastuzumab therapy in HER2-positive breast cancer patients. We analyzed the induction of HER2 specific CD8+T cells before and after trastuzumab therapy by tetramer assay and ELISPOT assay. HER2p369 specific CD8+T cells after trastuzumab were detected in only HER2-positive metastatic breast cancer patients. We could not detect HER2-specific CD8+T cells in early breast cancer patients after trastuzumab.
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