2010 Fiscal Year Final Research Report
The research for immunotherapy used by gd T cells
| Project/Area Number |
21791249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
YOSHIZAWA Atsushi Kyoto University, 医学研究科, 特定助教 (60457984)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 肝移植 / 移植免疫 / γδT細胞 |
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| Research Abstract |
In this study, we found the increase of γδ T cells in the peripheral blood from pediatric living donor liver transplantation recipients. The feature of gd T cells from recipients is the oligoglonal expansion ; the TCR of γδ T cell showed Vd1 TCR and the variable region of Vδ1 chain showed mnoclonality. We succeeded the expansion of γδ T cell from PBMC of healthy volunteers in vitro, and those T cells showed the immunosuppressive activity. These immunosuppressive T cells will be applied to new immunosuppressive therapy by transfer of the cells.
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