The induction of autophagy in malignant glioma cells treated with natural compound

2011 Fiscal Year Final Research Report

• Project/Area Number: 21791349
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Niigata University
• Principal Investigator: AOKI Hiroshi 新潟大学, 医歯学総合病院, 特任助教 (30515771)
• Project Period (FY): 2009 – 2011
• Keywords: NF-kB / オートファジー / クルクミン / テモゾロマイド / 天然化合物 / 悪性神経膠腫 / 薬剤耐性

Research Abstract

Curcumin has high anticancer efficacy in vitro and in vivo by down-regulation of NF-kB, followed by induction of autophagy and autophagy. Targeting Autophagy through down-regulation of NF-kB is a new treatment strategy in patients with malignant glioma.

Research Products

• [Journal Article] Induction of autophagy in temozolomide treated malignant gliomas (2011)
  • Author(s): Natsumeda M, Aoki H, Miyahara H, Yajima N, Uzuka T, Toyoshima Y, Kakita A, Takahashi H, Fujii Y
  • Journal Title: Neuropathology Volume: 31(5) Pages: 486-93
  • DOI: doi:10.1111/j.1440-1789.2010.01197.x.
• [Presentation] 悪性神経膠腫におけるAutophagyの役割 (2011)
  • Author(s): 青木洋、岡田正康、小倉良介、小林勉、藤井幸彦
  • Organizer: 第12回分子脳神経外科学会
  • Year and Date: 20110000
• [Presentation] Autophagy (2010)
  • Author(s): 青木洋
  • Organizer: 脳神経研究会
  • Year and Date: 20100000
• [Presentation] Monitoring autophagy in malignant glioma with antibody against LC3B (2010)
  • Author(s): Hiroshi Aoki, Manabu Natsumeda, Seiji Kondo, Yukihiko Fujii
  • Organizer: 69th Annual Meeting of the Japanese Cancer Association
  • Year and Date: 20100000
• [Presentation] LC3B抗体を用いた悪性グリオーマのオートファジーモニタリング (2010)
  • Author(s): Hiroshi Aoki, Manabu Natsumeda, Seiji Kondo, Yukihiko Fujii
  • Organizer: The 11th Annual Meeting of the Japan Society for Molecular Neurosurgery
  • Year and Date: 20100000
• [Presentation] オートファジー阻害薬を用いた新たな悪性グリオーマ治療の展開 (2009)
  • Author(s): 青木洋,篠島直樹,近藤靖子,近藤精二,藤井幸彦
  • Organizer: 第10回分子脳神経外科学会
  • Year and Date: 20090000
• [Presentation] オートファジーの役割に注目したテモゾロミド併用薬の検討 (2009)
  • Author(s): Hiroshi Aoki, Naoki Shinojima, Yasuko Kondo, Seiji Kondo, Yukihiko Fujii
  • Organizer: The 27th Annual Meeting of the Japan Society for Neuro-Oncology
  • Year and Date: 20090000
• [Presentation] INHIBITION OF TEMOZOLOMIDE-INDUCED AUTOPHAGY ENHANCES THE CYTOTOXIC EFFECT ON MALIGNANT GLIOMAS (2009)
  • Author(s): Hiroshi Aoki, Naoki Shinojima, Yasuko Kondo, Seiji Kondo, Yukihiko Fujii
  • Organizer: The 68th Annual Meeting of the Japanese Cancer Association
  • Year and Date: 20090000
• [Presentation] Selective H^+-ATPase inhibitor prevents the completion of autophagy induced by Temozolomide and emphasizes cytotoxicity in glioma cells (2009)
  • Author(s): Hiroshi Aoki, Naoki Shinojima, Yasuko Kondo, Seiji Kondo, Yukihiko Fujii
  • Organizer: The 3rd Quadrennial Meeting of the World Federation of Neuro-Oncology
  • Year and Date: 20090000