2010 Fiscal Year Final Research Report
Elucidation of the mechanisms regulating bone metastasis and invasion via the interaction between tumor and bone microenvironment.
Project/Area Number |
21791381
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
|
Research Institution | Hokkaido University |
Principal Investigator |
WATANABE Takuya Hokkaido University, 大学院・医学研究科, 客員研究員 (00455643)
|
Project Period (FY) |
2009 – 2010
|
Keywords | 骨 / 軟部腫瘍学 |
Research Abstract |
We identify receptor activator of nuclear factor κB ligand (RANKL) as a tumor microenvironment-specific factor essential for high affinity to bone via integrin upregulation and the following osteoclast differentiation, utilizing oral squamous cell carcinoma as a model. In addition, in human synovial sarcoma that frequently occurs bone metastasis, the interaction between the tumor and endothelial cells promotes tumor angiogenesis, through Src famiy kinase-dependent VEGF expression in the tumor cells.
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Research Products
(8 results)