2010 Fiscal Year Final Research Report
Contributions of Cytogenetics and Molecular Genetics to the Diagnosis and Treatment of Malignant Soft Tissue Tumors
| Project/Area Number |
21791424
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Fukuoka University |
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Principal Investigator |
NISHIO Jun Fukuoka University, 医学部, 助教 (90360304)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 軟部腫瘍 / 悪性線維性組織球腫 / 脂肪肉腫 / 色素性絨毛結節性滑膜炎 / 細胞株 |
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| Research Abstract |
We established a new permanent human malignant fibrous histiocytoma cell line. Molecular cytogenetic analyses revealed a homozygous deletion of p16 and a high-level amplification of 9q31-34 in this cell line. CSFJ rearrangement was identified in about 60% of pigmented villonodular synovitis/giant cell tumor of tendon sheath cases. Also, the presence of CSFIR amplification was not identified in any cases examined. High-level amplification of 12q13-15 was found in well-differentiated liposarcomas and dedifferentiated liposarcomas but not in benign adipocytic tumors.
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[Journal Article] Serum CA 125 expression as a tumor marker for diagnosis and monitoring the clinical course of epithelioid sarcoma.2010
Author(s)
Hoshino M, Kawashima H, Ogose A, Kudo N, Ariizumi T, Hotta T, Umezu H, Hatano H, Morita T, Nishio J, Iwasaki H, Endo N.
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Journal Title
J Cancer Res Clin Oncol 136(3)
Pages: 457-464
Peer Reviewed
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