2010 Fiscal Year Final Research Report
Molecular mechanisms for the development of morphine tolerance in neuropathic pain
Project/Area Number |
21791436
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Anesthesiology/Resuscitation studies
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Research Institution | Chiba University |
Principal Investigator |
DOBASHI Tamae Chiba University, 医学部附属病院, 助教 (10375694)
|
Project Period (FY) |
2009 – 2010
|
Keywords | ストレス / 蛋白 / 脳・神経 |
Research Abstract |
Morphine is a potent analgesic, but the molecular mechanism for tolerance formation for neuropathic pain is not fully understood. Recent studies have suggested that chronic endoplasmic reticulum (ER) stress might modulate intracellular signaling pathways, resulting in several chronic disorders, such as type II diabetes and interstitial pneumonia. We found that a chemical chaperone which improves ER protein folding capacity has a tendency to attenuate the development of morphine tolerance in wild-type mice with neuropathic pain, suggesting a possible clinical application of chemical chaperones in preventing morphine tolerance.
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Research Products
(7 results)