2011 Fiscal Year Final Research Report
Effects of general anesthetics on glucose metabolism in fed rats with hemorrhagic shock and ischemia/reperfusion
| Project/Area Number |
21791437
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 糖代謝 / 全身麻酔 / 嫌気的代謝 / 出血性ショック / 虚血再灌流 |
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| Research Abstract |
When compared to sevoflurane anesthesia, propofol anesthesia enhances insulin secretion under aerobic as well as anaerobic conditions. It is probable that adenosine triphosphate-sensitive potassium channels in beta-islet cells are involved in the different effects of sevoflurane anesthesia and propofol anesthesia on insulin secretion. Changes in both insulin secretion and insulin sensitivity during ischemia/reperfusion under propofol anesthesia are markedly different from those under sevoflurane anesthesia. During ischemia/reperfusion under propofol anesthesia, changes in insulin sensitivity seemed to be correlated with changes in plasma tumor necrosis factor-alpha levels.
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