2010 Fiscal Year Final Research Report
Effects of GABAB receptors on Immune System in Airway Epithelium
| Project/Area Number |
21791444
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gifu University |
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Principal Investigator |
SUGIYAMA Yoko Gifu University, 医学系研究科, 助教 (70444255)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 気道 / 免疫 / シグナル伝達 / サイトカイン / ムチン / 麻酔薬 / GABA受容体 |
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| Research Abstract |
Propofol enhanced TNF α induced-IL8 production via GABAA receptors in human airway epithelial cells. GABAB receptor agonists had no effect on IL-8 production. Midazolam inhibited TGF α induced-MUC5AC production in a GABAA receptor independent manner. These results suggest that GABAA receptors may become a new therapeutic target of airway inflammation.
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