2011 Fiscal Year Final Research Report

Study of Antinociceptive Effect of Polyphenols in Rat Experimental Models

Research Project

Project/Area Number	21791481
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	NAKAMURA Motohiro 産業医科大学, 医学部, 助教 (30461578)
Project Period (FY)	2009 – 2011
Keywords	行動薬理学実験 / ポリフェノール / 神経障害性疼痛 / 鎮痛薬 / 動物モデル
Research Abstract	Several intrathecal polyphenols exerted antinociceptive effect on acute pain. In neuropathic pain model, some drugs attenuated mechanical allodynia but not thermal hyperalgesia, suggesting a weak antinociceptive property.