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2010 Fiscal Year Final Research Report

Comprehensive research on epigenetics in male infertility

Research Project

  • PDF
Project/Area Number 21791496
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKanazawa University

Principal Investigator

MAEDA Yuji  Kanazawa University, 医学系, 助教 (20377394)

Project Period (FY) 2009 – 2010
Keywordsエピジェネティックス / 精子形成
Research Abstract

The gene expression is selectively controlled. The individuality of the cell is determined by combination of activated genes so that it makes the physiological functions as the entire individual. Epigenetics is taking part as one of the control mechanisms of gene expression. Recent reports showed that epigenetic control is important in embryology or oncology. In mammalian spermatogenesis, spermatogenic cells develop into functional gametes through meiosis with complex gene expression. Our study suggested that certain genes important in spermatogenesis are involved in epigenetic control of its expression.

  • Research Products

    (5 results)

All 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in thetestis.2009

    • Author(s)
      Sugimoto K, Koh E, Sin HS, Maeda Y, Narimoto K, Izumi K, Kobori Y, Kitamura E, Nagase H, Yoshida A, Namiki M.
    • Journal Title

      J Hum Genet 54

      Pages: 450-456

    • Peer Reviewed
  • [Presentation] ALF gene promoter hypermethylationがTESE-ICSI成績に与える影響2009

    • Author(s)
      杉本和宏, 中嶋一史, 中嶋孝夫, 島村正喜, 泉浩二, 成本一隆, 前田雄司, 溝上敦, 高栄哲, 並木幹夫, 吉田淳, 北村栄子, 永瀬浩喜
    • Organizer
      第46回日本生殖医学会北陸支部学術総会
    • Place of Presentation
      金沢ニューグランドホテル(金沢市)
    • Year and Date
      2009-06-07
  • [Presentation] Impact ofaberrant ALF gene methylation onoutcome of testicular sperm extractionand intracytoplasmic sperm injection2009

    • Author(s)
      Kazuhiro Sugimoto, Kouji Izumi, Kazutaka Narimoto, Sotaro Miwa, YujiMaeda, Tohru Miyagi, Jiro Kanaya, Yasuhide Kitagawa, Yoshihumi Kadono, Hiroyuki Konaka, Atsushi Mizokami ,Eitetsu Koh, Mikio Namiki
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Mc Cormick Place West Building(Chicago, IL, USA)
    • Year and Date
      2009-04-27
  • [Presentation] TESE-ICSIがDNAメチル化異常による精子形成障害を治療できる可能性2009

    • Author(s)
      杉本和宏, 申湖水, 前田雄司, 金谷二郎, 高栄哲, 並木幹夫, 吉田淳, 北村栄子, 永瀬浩喜
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Year and Date
      2009-04-19
  • [Presentation] ALF遺伝子にみられるpromoter hypermethylation -エピジェネティック疾患としての精子形成障害の可能性-2009

    • Author(s)
      杉本和宏, 下田ちはる, 申湖水, 前田雄司, 高栄哲, 並木幹夫, 吉田淳, 北村栄子, 永瀬浩喜
    • Organizer
      第13回北陸泌尿器科BasicResearch Meeting
    • Place of Presentation
      ホテル金沢(金沢市)
    • Year and Date
      2009-02-21

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Published: 2012-02-13   Modified: 2016-04-21  

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