The role of immune cells in the etiology of endometriosis

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791543
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: KOUGA Kawori 東京大学, 医学部附属病院, 助教 (10396723)
• Project Period (FY): 2009 – 2010
• Keywords: 子宮内膜症 / 免疫 / 樹状細胞

Research Abstract

DCs phagocyte endometrial cell in retrograde menstruation and provoke inflammation and in turn contribute to the progress endometriosis.

Research Products

• [Journal Article] Proteinase-activated receptors in the endometrium and endometriosis (2012)
  • Author(s): Osuga Y, Hirota Y, Yoshino O, Hirata T, Koga K, Taketani Y.
  • Journal Title: Front Biosci (Schol Ed) Volume: 1;4 Pages: 1201-12
  • Peer Reviewed
• [Journal Article] Activin-A is induced by interleukin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma (2011)
  • Author(s): Yoshino O, Izumi G, Shi J, Osuga Y, Hirota Y, Hirata T, Harada M, Nishii O, Koga K, Taketani Y.
  • Journal Title: Fertil Steril Volume: 96(1) Pages: 118-21
  • Peer Reviewed
• [Journal Article] Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis (2011)
  • Author(s): Hirata T, Osuga Y, Takamura M, Saito A, Hasegawa A, Koga K, Yoshino O, Hirota Y, Harada M, Taketani Y.
  • Journal Title: Fertil Steril Volume: 96(1) Pages: 113-7
  • Peer Reviewed
• [Journal Article] TGF-β1 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6 (2011)
  • Author(s): Saito A, Osuga Y, Yoshino O, Takamura M, Hirata T, Hirota Y, Koga K, Harada M, Takemura Y, Yano T, Taketani Y.
  • Journal Title: Hum Reprod Volume: 26(7) Pages: 1892-8
  • Peer Reviewed
• [Journal Article] Dienogest, a new conservative strategy for extragenital endometriosis: a pilot study (2011)
  • Author(s): Harada M, Osuga Y, Izumi G, Takamura M, Takemura Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y.
  • Journal Title: Gynecol Endocrinol Volume: 27(9) Pages: 717-20
  • Peer Reviewed
• [Journal Article] Lymphocytes in endometriosis (2011)
  • Author(s): Osuga Y, Koga K, Hirota Y, Hirata T, Yoshino O, Taketani Y.
  • Journal Title: Am J Reprod Immunol Volume: 65(1) Pages: 1-10
  • DOI: doi:10.1111/j.1600-0897.2010.00887.x.
  • Peer Reviewed
• [Journal Article] Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells. (2010)
  • Author(s): Hirata T, Osuga Y, Takamura M, Kodama A, Hirota Y, Koga K, Yoshino O, Harada M, Takemura Y, Yano T, Taketani Y.
  • Journal Title: Endocrinology Volume: 151(11) Pages: 5468-76
  • Peer Reviewed
• [Journal Article] Successful management of a ruptured endometrial cyst in acute leukemia (2010)
  • Author(s): Taguchi A, Koga K, Osuga Y, Fujimoto A, Miyasaka A, Yano T, Kurokawa M, Taketani Y.
  • Journal Title: Fertil Steril Volume: 95(1) Pages: e1-3
  • Peer Reviewed
• [Journal Article] Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision (2009)
  • Author(s): Takamura M, Koga K, Osuga Y, Takemura Y, Hamasaki K, Hirota Y, Yoshino O, Taketani Y.
  • Journal Title: Hum Reprod Volume: 24(12) Pages: 3042-8
  • Peer Reviewed