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2010 Fiscal Year Final Research Report

The Role of Maternal Aging in the Fetal Programming Hypothesis

Research Project

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Project/Area Number 21791550
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionMie University

Principal Investigator

UMEKAWA Takashi  Mie University -> 三重大学, 医学部附属病院, 助教 (80422864)

Project Period (FY) 2009 – 2010
Keywords母体生活環境 / 食生活の欧米化 / 高脂肪食 / 胎児プログラミング / DOHaD / 高血圧 / 糖脂質代謝異常
Research Abstract

In order to clarify the role of maternal excess fat intake in the fetal programming, we investigated the effects of a maternal high-fat diet before and during pregnancy on blood pressure and glucose and lipid metabolism in offspring. As a result, a maternal high-fat diet before and during pregnancy predisposes their offspring to hypertension and to the disturbance of glucose and lipid metabolism in adult life.

Research Products

(13 results)

All 2010 2009 Other

All Journal Article Presentation Remarks

  • [Journal Article] Transgenic mice overproducing human thioredoxin-1, an antioxidative and anti-apoptotic protein, prevents diabetic embryopathy.2010

    • Author(s)
      Kamimoto Y, Sugiyama T, Kihira T, Zhang L, Murabayashi N, Umekawa T, 他5名
    • Journal Title

      Diabetologia. 第53巻

      Pages: 2046-2055

    • Peer Reviewed
  • [Journal Article] Placental Glucocorticoid Metabolism is Modulated by Antioxidant System and Affects Pancreatic Function of the Offspring in Later Life.2010

    • Author(s)
      Umekawa T, 他5名
    • Journal Title

      Diabetes. 第59巻

      Pages: A445-A446

    • Peer Reviewed
  • [Journal Article] Maternal nutrition modulate adipocytokine expression in the fetal adipose tissue.2010

    • Author(s)
      Sagawa N, Murabayashi N, Sugiyama T, Yura S, Itoh H, Umekawa T, Zhang L.
    • Journal Title

      Endocrine Journal. 第57巻

      Pages: S298

    • Peer Reviewed
  • [Journal Article] Dynamic changes of macrophage subtype M1 and M2 in adipose tissue contribute to insulin resistance in pregnancy in a diet-induced obesity mouse model.2010

    • Author(s)
      Zhang L, Sugiyama T, Murabayashi N, Umekawa T, 他4名
    • Journal Title

      Endocrine Journal. 第57巻

      Pages: S407

    • Peer Reviewed
  • [Journal Article] Fetal growth and metabolic change in high-fat diet (HFD)-induced obese pregnant mice.2010

    • Author(s)
      Murabayashi N, Sugiyama T, Zhang L, Umekawa T, Sagawa N
    • Journal Title

      Endocrine Journal. 第57巻

      Pages: S438

    • Peer Reviewed
  • [Journal Article] Universal screening for gestational diabetes in Japan.2010

    • Author(s)
      Sugiyama T, Murabayashi N, Zhang L, Umekawa T, 他3名
    • Journal Title

      Endocrine Journal. 第57巻

      Pages: S381

    • Peer Reviewed
  • [Presentation] 当科における精神疾患合併妊娠に関する検討-精神科入院例における育児の視点から2010

    • Author(s)
      梅川孝、他5名
    • Organizer
      第46回日本周産期・新生児学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-07-13
  • [Presentation] Placental Glucocorticoid Metabolism is Modulated by Antioxidant System and Affects Pancreatic Function of the Offspring in Later Life2010

    • Author(s)
      Umekawa T, 他5名
    • Organizer
      American Diabetes Association 70th Scientific Sessions
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2010-06-27
  • [Presentation] human thioredoxin-1 (hTRX-1)による抗酸化系機構が出生後の糖代謝に及ぼす影響-膵臓糖代謝関連因子遺伝子発現の検討2010

    • Author(s)
      梅川孝、他4名
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-25
  • [Presentation] Placental Glucocorticoid Metabolism is Modulated by Antioxidant System and Affects Pancreatic Function of the Offspring in Later Life2010

    • Author(s)
      Umekawa T,, 他4名
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-28
  • [Presentation] 当科におけるBasedow病合併妊娠に関する検討2009

    • Author(s)
      梅川孝、他4名
    • Organizer
      第45回日本周産期・新生児学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-13
  • [Presentation] human thioredoxin-1 (hTRX-1)による抗酸化系機構が出生後の糖代謝に及ぼす影響-離乳期と成獣期における検討2009

    • Author(s)
      梅川孝、他4名
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-03
  • [Remarks] ホームページ等

    • URL

      http://www.medic.mie-u.ac.jp/sanfujinka/

URL: 

Published: 2012-02-12   Modified: 2016-04-21  

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