2010 Fiscal Year Final Research Report
Novel function of hTERT and its application to cancer therapy
| Project/Area Number |
21791579
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa University |
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Principal Investigator |
MAIDA Yoshiko Kanazawa University, 医学系, 助教 (20397219)
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| Project Period (FY) |
2009 – 2010
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| Keywords | テロメレース / 機能性RNA |
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| Research Abstract |
hTERT elongates telomere through its telomere-specific RNA dependent DNA polymerase activity. Accumulating evidence indicates hTERT has other function(s) beyond telomere maintenance. We identified RMRP as a novel binding partner of hTERT. hTERT-RMRP complex exhibited RNA dependent RNA polymerase (RdRP) activity and synthesized complementary strand of RMRP in vivo. The short RNA derived from the product of the RdRP activity was supposed to be involved in RNA silencing.
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[Journal Article] An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.2009
Author(s)
Maida, Y., Yasukawa, M., Furuuchi, M.,Lassmann, T., Possemato, R., Okamoto,N., Kasim, V., Hayashizaki, Y., Hahn,W.C., Masutomi, K.
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Journal Title
Nature 461
Pages: 230-235
Peer Reviewed
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