2010 Fiscal Year Final Research Report

Basic research for denervation and aberrant nerve reinnervation in aged animal models

Research Project

Project/Area Number	21791624
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Kumamoto University
Principal Investigator	MIYAMARU Satoru Kumamoto University, 大学院・生命科学研究部, 助教 (10535636)
Project Period (FY)	2009 – 2010
Keywords	加齢 / 脱神経 / 反回神経麻痺 / 神経再支配 / 神経筋弁移植
Research Abstract	We evaluated the effects of reinnervation procedures on the denervated thyroarytenoid (TA) muscle in aged rats. For the reinnervation procedure, we implanted the nerve-muscle pedicle (NMP), the ansa cervicalis nerve branch with a piece of sternohyoid muscle, in the denervated TA muscle. The NMP method could recover the denervation atrophy of TA muscle and the denervated TA muscle was reinnervated through the transferred ansa cervicalis nerve. We confirmed that the reinnervation procedures, by use of other nerves could recover the atrophic changes of the denervated muscles even in aged models.