2011 Fiscal Year Final Research Report
A clarification of the mechanism that B cell tolerance induced by liver sinusoidal endothelial cells and application to the clinical treatment against humoral rejection.
| Project/Area Number |
21791731
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
IGARASHI Yuka 広島大学, 大学院・医歯薬学総合研究科, 研究員 (10531692)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 移植・再生医療 / 糖鎖 / 免疫 / 外科 / トランスレーショナルリサーチ |
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| Research Abstract |
We have recently shown that B cells tolerance to donor blood group-A antigens develops following blood group A-to-O pediatric liver transplantation. Blood group antigen-reactive B cells might be tolerized through their interaction with liver sinusoidal endothelial cells(LSECs), which exclusively express blood group antigens together with PDL-1.
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