2011 Fiscal Year Final Research Report
Drugs improve mouse cognitive function by increasing the production of insulin-like growth factor-I
Project/Area Number |
21791771
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Emergency medicine
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Research Institution | Nagoya City University |
Principal Investigator |
NARIMATSU Noriko 名古屋市立大学, 大学院・医学研究科, 研究員 (50381794)
|
Project Period (FY) |
2009 – 2011
|
Keywords | 脳・神経 / リハビリテーション |
Research Abstract |
Insulin-like growth factor-I(IGF-I) exerts beneficial effects on cognitive function. Because stimulation of sensory neurons induces IGF-I production by releasing calcitonin gene-related peptide(CGRP) in the mouse brain, we hypothesized that donepezil may have a stimulatory effect on sensory neurons in addition to an inhibitory effect on acetylcholinesterase, thereby promoting angiogesis and neurogenesis through an increase in IGF-I production in the hippocampus. To examine this possibility, we analyzed the effects of two selective acetylcholinesterase inhibitors(donepezil and tacrine) on hippocampal IGF-I production and cognitive function in WT mice, CGRP-knockout[CGRP(-/-)] mice, and WT mice with functional sensory denervation caused by neonatal administration of capsaicin.
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Research Products
(5 results)