2010 Fiscal Year Final Research Report
The regulation of Fgf23 gene expression by inorganic phosphate
| Project/Area Number |
21791782
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAMAMURA Yoshihiro Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 特任助教 (70431963)
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| Project Period (FY) |
2009 – 2010
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| Keywords | Fgf23 / 骨細胞 / 無機リン / マウス |
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| Research Abstract |
The expression of Fgf23 was regulated in bone in response to the change of serum concentration of inorganic phosphate. Calvaria was more sensitive than long bone to induce the expression of Fgf23. The expression of Fgf23 might not be regulated by direct effects of serum phosphate but by in concert with systemic factors. Cell types in bone should be elucidated in response to the change of the serum concentration of inorganic phosphate.
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