2011 Fiscal Year Final Research Report
Shh signaling is related to Bmp signaling in ameloblast differentiation and tooth reconstruction
| Project/Area Number |
21791838
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAKAHASHI Satomi 東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 (40451918)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWASHIMA Nobuyuki 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (60272605)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯の発生 / エナメル芽細胞 / Sonic hedgehog / Gli / Bone morphogenetic protein / Smad / Wnt |
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| Research Abstract |
Tooth development is regulated by various intercellular signaling molecules, such as sonic hedgehog (Shh), bone morphogenetic proteins (BMPs), Wnts and fibloblasts growth factors. These molecules are also essential for ameloblast differentiation. We reported that Shh signaling was indispensable for ameloblast development. In ameloblast, Shh, BMPs and Wnts expressions are observed in their early stage of development, along with their receptor molecules. These observations suggest the involvement of Shh, BMPs and Wnts signaling in the differentiation of ameloblasts. We revealed that Shh induced the expression of BMPs and Wnts, suggesting that Shh may play a central role to activate the signaling network in ameloblasts.
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