2010 Fiscal Year Final Research Report
Analysis of molecular mechanism of inflammatory pain for pain control of pulpitis
| Project/Area Number |
21791849
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
NAGAYAMA Tomotaka Osaka University, 歯学部附属病院, 医員 (60456944)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 歯学 / シグナル伝達 / 神経科学 / 疼痛 / 炎症 |
|---|
| Research Abstract |
The regulation mechanism of CGRP expression and secretion induced by acid activation of TRPV1 signaling in DRG neurons, assuming local environment of inflammation, were investigated. Detailed analysis revealed that acid activation of TRPV1 lead to an up-regulation of CGRP expression via CREB-CaMK cascade.
|
Research Products
(2 results)
-
[Journal Article]2010
Author(s)
Masako Nakanishi, Kenji Hata, Tomotaka Nagayama, Teruhisa Sakurai, Toshihiko Nishisho, Hiroki Wakabayashi, Toru Hiraga,_Shigeyuki Ebisu, Toshiyuki Yoneda.
-
Journal Title
Molecular Biology of the Cell Vol.21
Pages: 2568-2577
Peer Reviewed
-
