2010 Fiscal Year Final Research Report
Basic resarch about application of targeted therapy by anaysis of cancer-associated gene in oral squamous cell carcinoma
Project/Area Number |
21791977
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
NAKAMURA Erina Tokyo Medical and Dental University, 歯学部附属病院, 医員 (20527022)
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Project Period (FY) |
2009 – 2010
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Keywords | 口腔外科学一般 |
Research Abstract |
We assessed copy-number alterations among the 21 OSCC cell lines by array-CGH .High-level amplifications were detected in Tosca 55 cell lines around 6q22.By FISH analysys,We recognized around 3.5 Mb amplification region. In this region,eight genes located according to the information archived by genome detabases.Next we determined the mRNA expression levels of eight genes in 21 OSCC cell lines .Among eight genes,three genes were expressed in most of the OSCC cell lines,suggesting that these genes are the target for 6q22 amplification region.
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Research Products
(2 results)