2010 Fiscal Year Final Research Report
Relationship of cytoplasmic capping to translation and cell stress
| Project/Area Number |
21870020
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Osaka University |
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Principal Investigator |
OTSUKA Yuichi Osaka University, 大学院・理学研究科, 助教 (10548861)
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| Project Period (FY) |
2009 – 2010
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| Keywords | mRNA / キャップ構造 / 細胞ストレス / 大腸菌 / T4ファージ / トキシン-アンチト / キシン |
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| Research Abstract |
The purpose of this research project is to verify that capping can occur in cytoplasm as well as nucleus, and show the significance of cytoplasmic capping in gene expression. I identified many target mRNAs to which cap structures would be added in cytoplasm. Also, deep sequencing analysis suggested that some of these mRNAs might have poly(U) tail at 3' terminus. These modifications on mRNA may play important roles in gene expression. In a different research project, I showed that bacteriophage T4 had an antitoxin against E.coli toxins for its own survival.
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