2010 Fiscal Year Final Research Report
Development of real-time assessment technology and care methodology based on wound infection pathogenesis
| Project/Area Number |
21890064
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Community health/Gerontological nurisng
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAGAMI Gojiro The University of Tokyo, 大学院・医学系研究科, 講師 (70547827)
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| Project Period (FY) |
2009 – 2010
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| Keywords | クオラムセンシング / 褥瘡 / 感染 / 遺伝子発現 |
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| Research Abstract |
It is still unclear that how bacteria invade the wound and cause wound infection. In the present study, the researcher focused on quorum sensing signal molecule, acylated homoserine lactone (AHL) as a key target for wound infection pathogenesis. By applying the AHL to the granulation tissue of full-thickness wound in rats, marked inflammatory reaction was observed. The specific up-regulation of matrix metalloproteinase (MMP) consisting of AP-1 on their promoter region was observed in AHL treated fibroblastic cell lines. The researcher further revealed that AP-1/MAPK signaling was considered to be involved in AHL induced MMP up-regulation. These results indicated the new insights for understanding the mechanism of wound infection through quorum sensing signaling.
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