2010 Fiscal Year Final Research Report
A novel mechanism for inhibition of TGF-β family signaling by HTRA1
| Project/Area Number |
21890079
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
NOZAKI Hiroaki Niigata University, 医歯学総合病院, 助教 (20547567)
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| Project Period (FY) |
2009 – 2010
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| Keywords | CARASIL / TGF-β / BMP-2 / BMP-4 / small vessel disease |
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| Research Abstract |
HTRA1, a serine protease, decreases the signaling of TGF-β family members such as TGF-β and BMPs, but the mechanism remains unkown. TGF-β and BMPs are synthesized as a proprotein and cleaved into mature form by furin in the trans-Golgi network. This study elucidated that HTRA1 cleaves the proprotein in the endoplasmic reticulum, resulting in reduced mature form and decreased the signaling by interfering with furin-dependent cleavage of TGF-β family members.
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