2010 Fiscal Year Final Research Report
Pathogenesis of nonalcoholic steatohepatitis (NASH) via aryl hydrocarbon receptor signaling
Project/Area Number |
21890139
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Gastroenterology
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Research Institution | Kobe University |
Principal Investigator |
MIKI Akira Kobe University, 医学部附属病院, 特定助教 (40514964)
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Project Period (FY) |
2009 – 2010
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Keywords | NASH / NAFLD / AhR |
Research Abstract |
Non-alcoholic fatty hepatitis (NASH) is the progressive disease developing from the simple fatty liver disease to hepatitis and furthermore hepatic cirrhosis and cancer, and has a poor prognosis. The animal experiments have demonstrated the interrelationship among environmental contaminants, defective lipid metabolism and the pathogenesis of fatty liver, and these results raise the possibility that environmental contaminants are involved in the pathogenesis of NASH. Multiple environmental contaminants binds to aryl hydrocarbon receptor (AhR), resulting in enhancing various reactions. Therefore, we investigated whether the AhR activation by environmental contaminants leads to progression of NASH.
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Research Products
(11 results)
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[Journal Article] Activation of Aryl Hydrocarbon Receptor Induces Hepatic Steatosis via Upregulation of Fatty Acid Transport.2010
Author(s)
Kawano Y, Nishiumi S, Tanaka S, Nobutani K, Miki A, Yano Y, Seo, Y, Ashida H, Kutsumi H, Azuma T, Yoshida M.
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Journal Title
Arch Biochem Biophys. 504(2)
Pages: 221-227
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