2010 Fiscal Year Final Research Report
Development of a novel method of promoting alveolar bone formation by controlling the expression of BMP antagonist.
| Project/Area Number |
21890149
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
FUJISAWA Takuo Okayama University, 岡山大学病院, 助教 (20325096)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 質細胞 / BMP / BMPアンタゴニスト / siRNA |
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| Research Abstract |
The purpose of this study is to identify the BMP antagonists which expressed during osteogenic differentiation induced by BMP-2 and develop a novel method for promoting alveolar bone formation by controlling the expression of those antagonists. In this study, I demonstrate knockdown of SOST by RNA interference in vitro resulted in a significant increase in the expression of the osteogenic marker alkaline phosphatase and the deposition of extracellular mineral, in response to osteogenic stimulation.
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