2010 Fiscal Year Final Research Report
Study of pathogenic mechanism of respiratory inflammation and investigation of involvement of epigenetic regulation
| Project/Area Number |
21890174
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kochi University |
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Principal Investigator |
EITOKU Masamitsu Kochi University, 教育研究部・医療学系, 助教 (50552733)
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| Project Period (FY) |
2009 – 2010
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| Keywords | インジウム化合物 / 産業医学 / エピジェネティクス / 酸化ストレス / 呼吸器炎症 |
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| Research Abstract |
I performed intratracheal instillation of indium oxide (In_2O_3) using acatalasemic mice which lack the activity of catalase. Comparison of acatalasemic and wild-type mice showed significant difference in body weight change, increasing of relative lung weight and damage of lung tissue after 9 weeks, twice in a week instillation.
In the field of the indium-compound toxicity study, these results showed the involvement of oxidative stress to lung damage caused by exposure to indium compounds and gave us novel cue for future research.
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