2010 Fiscal Year Final Research Report
Potential of Induced Pluripotent Stem (iPS) Cells for the Regeneration of the Tracheal Wall
| Project/Area Number |
21890207
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
IMAIZUMI Mitsuyoshi Fukushima Medical University, 医学部, 助手 (30554422)
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| Project Period (FY) |
2009 – 2010
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| Keywords | iPS細胞 / 軟骨分化誘導 / 気管再生 |
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| Research Abstract |
Our study demonstrated that iPS cells have the potency to differentiate into chondrogenic cells, as shown by the appearance of Alcian blue-stained colonies and expression of a cartilage-associated gene of collagen type II in vitro. Implanted iPS cells were confirmed to exist in the 3D scaffold in vivo. Cartilage-like tissue was regenerated in tracheal defect using iPS cells. Our results suggest the potential of iPS cells for the regeneration of the tracheal wall.
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