2010 Fiscal Year Final Research Report
Urate transport via human voltage-driven organic anion transporter OATv1 : Mechanism for diuretics-induced hyperuricemia
| Project/Area Number |
21890245
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyorin University |
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Principal Investigator |
JUTABHA Promsuk Kyorin University, 医学部, 助教 (90541748)
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| Project Period (FY) |
2009 – 2010
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| Keywords | トランスポーター / 有機酸 / 電位依存性 / 尿酸 / 利尿薬 / パラアミノ馬尿酸 |
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| Research Abstract |
Since sodium-dependent phosphate transporter NPT at the apical membrane of renal proximal tubules in human is considered to be OATv1 which mediates the extrusion of organic anions with voltage-dependent manner, I analyzed its urate-transport properties to clarify the molecular mechanism for diuretics-induced hyperuricemia targeting human OATv1. During this period, I observed voltage-dependent transport of both PAH and urate labeled with radio isotope and concentration-dependent inhibition on OATv1-mediated transport by diuretics. Thus, it is suggested that reduction of urate secretion by the competition between urate and diuretics targeting OATv1 leads to the development of diuretics-induced hyperuricemia.
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[Journal Article] Human sodium-phosphate transporter 4(hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate.2010
Author(s)
Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H
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Journal Title
J Biol Chem. 285巻
Pages: 35123-35132
Peer Reviewed
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[Journal Article] A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules.2010
Author(s)
Shiraya K, Hirata T, Hatano R, Nagamori S, Wiriyasermkul P, Jutabha P, Matsubara M, Muto S, Tanaka H, Asano S, Anzai N, Endou H, Yamada A, Sakurai H, Kanai Y
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Journal Title
J Biol Chem. 285巻
Pages: 22141-51
Peer Reviewed
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