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2010 Fiscal Year Final Research Report

Search for natural products targeting Pokemon signaling pathway

Research Project

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Project/Area Number 21890268
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Drug development chemistry
Research InstitutionHoshi University

Principal Investigator

HOYOYA Takahiro  Hoshi University, 薬学部, 研究員 (30506572)

Project Period (FY) 2009 – 2010
Keywords天然物 / ポケモン / 肺がん / スクリーニング / シグナル伝達
Research Abstract

Pokemon (POK erythroid myeloid ontogenic factor ; LRF, FBI1, ZBTB7A) is a transcriptional suppressor. It is reported that the overexpression of Pokemon in lung cancer cell caused oncogenesis or maintain of the cancer. To search for inhibitors of the Pokemon signaling pathway, new cell-based assay systems were developed and screening of natural product or natural resources have been performed.

  • Research Products

    (3 results)

All 2011 2010

All Journal Article (2 results) Presentation (1 results)

  • [Journal Article] Inhibitors of Nitric Oxide Production from Stemona javanica.2011

    • Author(s)
      Hosoya, Takahiro; Yamasaki, Fumie; Nakata, Asami; Rahman, Abdul; Kusumawati, Idha; Zaini, Noor Cholies; Morita, Hiroshi
    • Journal Title

      Planta Medica 77

      Pages: 256-258

  • [Journal Article] Papuabalanols A and B, new tannins from Balanophora papuana.2010

    • Author(s)
      Hosoya, Takahiro; Nakata, Asami; Zaima, Kazumasa; Latip, Jalifah; Din, Laily Bin; Muslim, Noramly; Morita, Hiroshi
    • Journal Title

      Chemical & Pharmaceutical Bulletin 58

      Pages: 738-741

  • [Presentation] ツチトリモチ科Balanophora papanaの成分に関する研究2010

    • Author(s)
      細谷孝博、森田博史、Noramly Muslim、Laily Din
    • Organizer
      第56回日本生薬学会
    • Place of Presentation
      京都
    • Year and Date
      20100000

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Published: 2012-01-26   Modified: 2016-04-21  

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