2021 Fiscal Year Annual Research Report
ウイルス捕捉・濃縮用の人工骨基材ナノフィルターの開発
| Project/Area Number |
21F21723
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
打越 哲郎 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー (90354216)
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| Co-Investigator(Kenkyū-buntansha) |
HASSAM CHRISTOPHER 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 外国人特別研究員
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| Project Period (FY) |
2021-07-28 – 2023-03-31
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| Keywords | Nanofilter / Viral capture / Hydroxy apatite / Hydrothermal synthesis / EPD / Silicon carbide |
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| Outline of Annual Research Achievements |
Our focus was on optimizing the hydroxyapatite (HAp) for use as a filter membrane. Initial optimizations were performed on a hydrothermal method and large-scale quantities of needle-like HAp were successfully prepared as free-standing filter membranes and as a coating on different substrates.
To improve the stability, inclusion of an elongated "whisker-like" form of HAp was attempted, with the synthesis based on a fatty-acid mediated solvothermal synthesis. Filters prepared from this whisker-like HAp show improved flexibility and resilience.
Successful use of free-standing membranes of HAp as filter material capable of separating 50 nm polystyrene spheres from aqueous solution without destruction or dissolution of the films. Triethanolamine is the current best performing dispersant for EPD.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
Current work is based on the production of water-stable films of HAp on SiC and their evaluation as filter material. The aim of the filter materials is to produce an environmentally friendly, and reusable membrane made from the desired materials. Different binders are being trialled for their suitability. Testing so far has encompassed inorganic binders (MgO2, TiO2, and SiO2) and polymeric organic binders.
Slight issue with optimization of the SiC based materials, due to the natural variation in conductivity in the SiC samples. Alternative method developed using a conductive backing layer in contact with the SiC, but covered itself in non-conductive polymer.
Now that most of the material optimization is complete, we can move steadily forward.
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| Strategy for Future Research Activity |
Initial plan was to produce a filter apparatus and measure the filtration efficiency using this, however, after discussion with the partners of the LINK laboratory, access to a filtration set-up through Saint-Gobain, working with SiC filters is available. Cylindrical (as well as planar) filters will be optimized using this apparatus for filtration efficiency, and resiliency.
Filter optimization to commence based on their performance in terms of filter stability, solvent flux, and separation efficiency. Further, selectivity of the filter membranes will be established by the production of polymer particles with different surface functionalities, different sizes, and mixtures of them. Flux measurements will monitor solvent flux during filtration, and after a number of filtration processes.
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