2023 Fiscal Year Final Research Report
Studies for plasmalogens, the discovered hypothalamic causative molecule to suppress reproductive functions due to lactation and ageing in cows
| Project/Area Number |
21H02345
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 42010:Animal production science-related
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
窪 友瑛 地方独立行政法人北海道立総合研究機構, 農業研究本部 酪農試験場, 研究主任 (50825338)
北村 進一 大阪公立大学, 研究推進機構, 特任教授 (60117869)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 乳牛 / 繁殖 |
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| Outline of Final Research Achievements |
Plasmalogens play crucial roles in maternal and breastfed infant bodies and stimulate gonadotropin secretion by gonadotrophs. To estimate changes in and importance of plasma concentrations in postpartum Holstein cows, plasma samples were collected from 3 weeks before expected parturition until approximately 8 weeks after parturition. The plasma concentrations declined before and increased after parturition and stabilised near the day of first postpartum ovulation (1stOV). The days from parturition to 1stOV correlated with days from parturition to conception. On the day of 1stOV, milk yield correlated with the plasma concentration. After the 1stOV, the plasma concentration correlated with plasma concentrations of both anti-Mullerian hormone and FSH. In conclusion, the plasmalogen concentrations changed dramatically around parturition and 1stOV, and the concentrations correlated with important parameters for milk production and reproduction.
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| Free Research Field |
繁殖
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| Academic Significance and Societal Importance of the Research Achievements |
乳牛の繁殖障害による分娩間隔延長は、多大な経済損失を世界中の酪農家で生じさせる。しかしそのメカニズムには不明点が多かった。本研究は、まず分娩間隔延長の主因は、分娩後の性機能の回復遅延である（P<0.05）ことを北海道の乳牛で調査し明らかにした。続いて、分娩後の性機能の回復遅延のメカニズムを、代表者の独自研究で発見した、下垂体のゴナドトロフにおける新規受容体GPR61と、そのリガンド、プラズマローゲン群に基づいて解明した。さらに初回排卵後の血中総プラズマローゲン濃度は、血中FSH濃度や乳量と正に相関することも発見した。これらは非常に重要な発見で、未開発の繁殖障害予防法の開発の基盤となる。
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