Clarify the role of mitochondria function on the development of fatty liver and hepatic carcinogenesis by targeting Apop-1

2022 Fiscal Year Annual Research Report

• Project/Area Number: 21H03369
• Research Institution: Mukogawa Women's University
• Principal Investigator: 福尾 惠介 武庫川女子大学, 食物栄養科学部, 教授 (40156758)
• Co-Investigator(Kenkyū-buntansha): 安田 修 鹿屋体育大学, スポーツ生命科学系, 教授 (00372615) ; 西川 浩樹 大阪医科薬科大学, 医学部, 教授 (30769609) ; 榎本 平之 兵庫医科大学, 医学部, 准教授 (40449880) ; 大谷 直子 大阪公立大学, 大学院医学研究科, 教授 (50275195) ; 横路 三有紀 武庫川女子大学短期大学部, 食生活学科, 講師 (80757188)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ミトコンドリア / 脂肪肝 / 肝発がん

Outline of Annual Research Achievements

本研究の目的は、我々が発見したミトコンドリアタンパク質Apop-1 に関する基礎研究と臨床研究により、高脂肪食によって誘導される肝発がんの発症機序を明らかにしようとするものである。基礎研究では、Apop-1ノックアウトマウスと野生型マウスを用いて、肝星細胞の細胞老化と老化した細胞から炎症や腫瘍の発生を促進する物質が分泌されるというSASPの病態や肝がん発症の程度について比較検討し、臨床研究では、脂肪肝患者を対象として、Apop-1 SNPと脂肪肝の病態や肝がん発症の程度との関係を検討する。（１）基礎研究：高脂肪食後の腸内細菌叢の違いの解析、マウス血中デオキシコール酸（二次胆汁酸）などの測定測定、組織学的解析（HE染色やオイルレッドO染色による形態学的な解析、CellROX○R試薬を用いたROS産生の検討、免疫組織染色によるp21、p16などの細胞老化指標、肝星細胞の指標であるα-SMA、desmin、SASPの指標であるIL-1βなどの解析）、定量PCRによるマウス組織よりtotal mRNAを抽出し、IL-6、IL-1βなどの発現を解析する。
（２）臨床研究　1) Apop-1 SNPとNASH発症・発がんとの関連の検討では、病理学的にNAFLD/NASHと確定診断された症例を対象とし、NASH患者の凍結肝組織や末梢血単核球から抽出されたDNA検体を用いる。これらのDNAを用いて、Apop-1 SNPを検討し、General populationのApop-1 SNPの多型比率と比較する。さらに、肝生検後の累積発癌率との関係を検討する。
2) Apop-1 SNPと腸内細菌叢との関係の検討では、NAFLD/NASH症例の腸内細菌叢を解析し、食事の摂取傾向との関係に与えるApop-1 SNPの影響について検討する。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

APOP1ノックアウトマウスを用いて、DMBAと高脂肪食摂取による化学肝発がん実験を行った。その結果、litter mateのWTマウスにおいては、平均30個/個体くらいの腫瘍形成を認めたが、APOP1ノックアウトマウスにおいては、体重変化はほとんどなかったにもかかわらず、ほんの数個しか腫瘍形成を認めず、APOP1ノックアウトマウスにおいて顕著な腫瘍形成の抑制を認めることが明らかになったため。また、臨床研究では、Apop-1 SNPにおいて、HCV 排除後 (N=51), NAFLD/NASH (N=82) いずれもApop-1のMinor alleleを有する例では脂肪化の程度や合併率が高い傾向にあることが明らかにすることができたため。

Strategy for Future Research Activity

APOP1は最近、電子伝達系複合体IVのアセンブリータンパク質COA8であることが判明している。今後、基礎研究においては、ミトコンドリアにおけるエネルギー代謝に着目し、腫瘍抑制を認めたメカニズムの解明を目指す。また、肝がん発症モデルにおいてもApopKOマウスにおいて肝臓の脂肪化抑制が認められたため、Apopが肝臓脂肪蓄積に関わる分子的機序の解明の手掛かりを得ることを目的としてApopKOマウスを用いた高脂肪食負荷実験時の肝臓サンプル（WT普通食群、WT高脂肪食群、ApopKO普通食群、ApopKO高脂肪食群、各３検体）のRNA抽出を行い、次世代シーケンス解析を行う。臨床研究においては、今後さらに症例数を増加して検討を行う。

Research Products

• [Journal Article] Association between asymmetric dimethylarginine and sarcopenia in community-dwelling older women (2023)
  • Author(s): Yokoro Miyuki、Otaki Naoto、Yano Megumu、Imamura Tomomi、Tanino Norikazu、Fukuo Keisuke
  • Journal Title: Scientific Reports Volume: 13 Pages: 5510
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• [Journal Article] Low Dietary Variety Is Associated with Incident Frailty in Older Adults during the Coronavirus Disease 2019 Pandemic: A Prospective Cohort Study in Japan (2023)
  • Author(s): Yokoro Miyuki、Otaki Naoto、Yano Megumu、Imamura Tomomi、Tanino Norikazu、Fukuo Keisuke
  • Journal Title: Nutrients Volume: 15 Pages: 1145～1145
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• [Journal Article] Associations between Dietary Variety and Frailty in Community-Dwelling Older People Who Live Alone: Gender Differences (2023)
  • Author(s): Yokoro M, Otaki N, Yano M, Tani M, Tanino N, Fukuo K.
  • Journal Title: J Frailty Aging Volume: 12 Pages: 30-36
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• [Journal Article] 漢字・食育融合教材の開発ー持続可能な学習機会の創出を目指して― (2023)
  • Author(s): 設樂馨, 𠮷井美奈子, 横路三有紀
  • Journal Title: 武庫川女子大学 学校教育センター紀要 Volume: 8 Pages: 43-56
  • Peer Reviewed
• [Journal Article] Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes (2022)
  • Author(s): Okina Y, Sato-Matsubara M, Kido Y, Urushima H, Daikoku A, Kadono C, Nakagama Y, Nitahara Y, Hoang TH, Thuy LTT, Matsubara T, Ohtani N, Ikeda K, Yoshizato K, Kawada N
  • Journal Title: Antioxid Redox Signal Volume: 38 Pages: 463-479
  • DOI: 10.1089/ars.2021.0279
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of Transcriptomic and Proteomic Changes in the Skin after Chronic Fluocinolone Acetonide Treatment (2022)
  • Author(s): Choi Y, Takasugi M, Takemura K, Yoshida Y, Kamiya T, Adachi J, Tsuruta D, Ohtani N
  • Journal Title: Biomolecules Volume: 12 Pages: 1822
  • DOI: 10.3390/biom12121822
  • Peer Reviewed / Open Access
• [Journal Article] Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus-Sustained Virological Response Patients. (2022)
  • Author(s): Dong MP, Thuy LTT, Hoang DV, Hai H, Hoang TH, Sato-Matsubara M, Hieu VN, Daikoku A, Hanh NV, Urushima H, Dat NQ, Uchida-Kobayashi S, Enomoto M, Ohtani N, Tamori A, Kawada N
  • Journal Title: Am J Pathol Volume: 192 Pages: 1379-1396
  • DOI: 10.1016/j.ajpath.2022.07.003
  • Peer Reviewed / Open Access
• [Journal Article] Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms (2022)
  • Author(s): Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N
  • Journal Title: Science Adv Volume: 8 Pages: eabo5525
  • DOI: 10.1126/sciadv.abo5525
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct responsiveness to rifaximin in patients with hepatic encephalopathy depends on functional gut microbial species (2022)
  • Author(s): Yukawa-Muto Y, Kamiya T, Fujii H, Mori H, Toyoda A, Sato I, Konishi Y, Hirayama A, Hara E, Fukuda S, Kawada N, Ohtani N
  • Journal Title: Hepatol Commun Volume: 6 Pages: 2090-2104
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  • Peer Reviewed / Open Access
• [Journal Article] Development and evaluation of a colorectal cancer screening method using machine learning-based gut microbiota analysis (2022)
  • Author(s): Konishi Y, Okumura S, Matsumoto T, Itatani Y, Nishiyama T, Okazaki Y, Shibutani M, Ohtani N, Nagahara H, Obama K, Ohira M, Sakai Y, Nagayama S, Hara E
  • Journal Title: Cancer Med Volume: 11 Pages: 3194-3206
  • DOI: 10.1002/cam4.4671
  • Peer Reviewed / Open Access
• [Journal Article] Non-heat-stressed Method to Isolate Hepatic Stellate Cells From Highly Steatotic Tumor-bearing Liver Using CD49a (2022)
  • Author(s): Cheng Y, Yamagishi R, Nonaka Y, Sato-Matsubara M, Kawada N, Ohtani N
  • Journal Title: Cell Mol Gastroenterol Hepatol Volume: 14 Pages: 964-966.e9
  • DOI: 10.1016/j.jcmgh.2022.07.006
  • Peer Reviewed / Open Access
• [Journal Article] Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma (2022)
  • Author(s): Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, Cheng Y, Nonaka Y, Yukawa-Muto Y, Thuy LTT, Harada Y, Arai T, Loo TM, Yoshimoto S, Ando T, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen WY, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N
  • Journal Title: Science Immunol Volume: 7(72): Pages: eabl7209
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  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species (2022)
  • Author(s): Hoang DV, Thuy LTT, Hai H, Hieu VN, Kimura K, Oikawa D, Ikura Y, Dat NQ, Hoang TH, Sato-Matsubara M, Dong MP, Hanh NV, Uchida-Kobayashi S, Tokunaga F, Kubo S, Ohtani N, Yoshizato K, Kawada N
  • Journal Title: Oncogenesis Volume: 11 Pages: 23
  • DOI: 10.1038/s41389-022-00389-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The role of cellular senescence and SASP in tumour microenvironment (2022)
  • Author(s): Takasugi M, Yoshida Y, Hara E, Ohtani N
  • Journal Title: FEBS J Volume: 290 Pages: 1348-1361
  • DOI: 10.1111/febs.16381
  • Peer Reviewed
• [Journal Article] Cellular senescence and the tumour microenvironment (2022)
  • Author(s): Takasugi M, Yoshida Y, Ohtani N
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  • Peer Reviewed
• [Journal Article] The role of immune cells in the liver tumor microenvironment: an involvement of gut microbiota-derived factors. (2022)
  • Author(s): Kamiya T, Ohtani N
  • Journal Title: Int Immunol Volume: 34 Pages: 467-474
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  • Peer Reviewed
• [Journal Article] The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis? (2022)
  • Author(s): Ohtani N
  • Journal Title: Inflamm Regen Volume: 42 Pages: 11
  • DOI: 10.1186/s41232-022-00197-8
  • Peer Reviewed
• [Journal Article] Risk stratification of decompensation using liver stiffness and platelet counts in compensated advanced chronic liver disease (CHESS2102) (2022)
  • Author(s): Liu Y., Liu C., Li J., Kim T.H., Enomoto H., Qi X
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  • Peer Reviewed
• [Journal Article] Modification of the ALBI-PLT Score for the Prediction of High-risk Varices. (2022)
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  • Journal Title: In Vivo Volume: 36 Pages: 1360-1366
  • Peer Reviewed
• [Journal Article] Possible Alterations in Appetite-related Molecules After the Elimination of Hepatitis C Virus (2022)
  • Author(s): Shimono Y., Enomoto H., Aizawa N., Takashima T., Ikeda N., Yuri Y., Fujiwara A., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Nishimura T., Iijima H
  • Journal Title: In Vivo Volume: 36 Pages: 1491-1496
  • Peer Reviewed
• [Journal Article] ABC: a novel algorithm to stratify decompensation risk in patients with compensated advanced chronic liver disease (CHESS2108): an international, multicenter cohort study (2022)
  • Author(s): Liu C., Li J., Wong Y.J., Xie Q., Hirooka M., Enomoto H., Kim T.H., Hanafy A.S., He R., Koizumi Y., Hiasa Y., Nishimura T., Iijima H., Jung Y.K., Yim H.J., Ma J., Zeng Q.L., Sarin S.K., Qi X.
  • Journal Title: Hepatol Int Volume: 6 Pages: 1105-1115
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Novel SAVE Score to Stratify Decompensation Risk in Compensated Advanced Chronic Liver Disease (CHESS2102): An International Multicenter Cohort Study. (2022)
  • Author(s): Liu C., Cao Z., Yan H., Wong Y.J., Xie Q., Hirooka M., Enomoto H., Kim T.H., Hanafy A.S., Liu Y., Huang Y., Li X., Kang N., Koizumi Y., Hiasa Y., Nishimura T., Iijima H., Jung Y.K., Yim H.J., Guo Y., Zhang L., Ma J, Kumar M, Jindal A, Teh KB, Sarin SK, Qi X.
  • Journal Title: Am J Gastroenterol Volume: 117 Pages: 1605-1613
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] No increased risk of hepatocellular carcinoma after eradication of hepatitis C virus by direct-acting antivirals, compared with interferon-based therapy (2022)
  • Author(s): Korenaga M., Murata K., Izumi N, Tamaki N., Yokosuka O., Takehara T., Sakamoto N., Suda G., Nishiguchi S., Enomoto H., Ikeda F.,et al
  • Journal Title: Glob Health Med Volume: 4 Pages: 216-224
  • Peer Reviewed
• [Journal Article] Diagnosis of hepatic steatosis based on ultrasound attenuation imaging is not influenced by liver fibrosis. (2022)
  • Author(s): Yuri M., Nishimura T., Tada T., Yoshida M., Fujiwara A., Kawata S., Yoshihara K., Yoshioka R., Ota S., Nakano R., Yuri Y., Takashima T., Aizawa N., Ikeda N., Shiomi H., Ide Y.H., Enomoto H., Yasuhiro F., Yano H., Iijima H
  • Journal Title: Hepatol Res Volume: 52 Pages: 1009-1019
  • Peer Reviewed
• [Journal Article] Liver cirrhosis in Japan: Future global trends in the era of progressive antiviral therapy. (2022)
  • Author(s): Enomoto H., Takashima T., Nishimura T., Aizawa N., Ikeda N., Yuri Y., Okamoto, M., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Iijima H
  • Journal Title: Port Hypertens Cirrhos Volume: 1 Pages: 178-183
  • Peer Reviewed
• [Journal Article] Clinical Characteristics of ICI-Related Pancreatitis and Cholangitis Including Radiographic and Endoscopic Findings (2022)
  • Author(s): Nakano R., Shiomi H., Fujiwara A., Yoshihara K., Yoshioka R., Kawata S., Ota S., Yuri Y., Takashima T., Aizawa N., Ikeda N., Nishimura T., Enomoto H., Iijima H
  • Journal Title: Healthcare Volume: 10 Pages: 76
  • Peer Reviewed
• [Journal Article] Acute Liver Failure and Acute-on-Chronic Liver Failure in COVID-19 Era (2022)
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• [Journal Article] Branched chain amino acid-to-tyrosine ratio: not only an indicator of the amino acid imbalance. (2022)
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  • Journal Title: Digestive Medicine Research. Dig Med Res Volume: 6 Pages: 1
  • Peer Reviewed
• [Journal Article] Multiple Inflammatory Pseudotumors of the Liver Demonstrating Spontaneous Regression: A Case Report. (2022)
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  • Journal Title: Life Volume: 12 Pages: 124
  • Peer Reviewed
• [Journal Article] Metastasis of Hepatocellular Carcinoma in the Pouch of Douglas Successfully Treated by Radiation Therapy: A Case Report (2022)
  • Author(s): Enomoto H., Fujiwara M., Kono H., Kako Y., Takahagi M., Taniguchi J., Ishikawa E., Ikeda N., Takashima T., Yuri Y., Aizawa N., Okamoto M., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Nishimura T., Hirota S., Yamakado K., Iijima H.
  • Journal Title: Life Volume: 13 Pages: 225
  • Peer Reviewed
• [Journal Article] Recanalization using a novel drill-shaped dilator for a severe pancreatic duct stricture and impacted pancreatic duct stone (2022)
  • Author(s): Shiomi H., Nakano R., Ota S., Nishimura T., Enomoto H., Iijima H
  • Journal Title: Endoscopy Volume: 55 Pages: E351-E353
  • Peer Reviewed
• [Journal Article] The Significance of Zinc in Patients with Chronic Liver Disease (2022)
  • Author(s): Nishikawa H, Asai A, Fukunishi S
  • Journal Title: Nutrients Volume: 14 Pages: 4855
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• [Journal Article] Grip Strength in Patients with Gastrointestinal Diseases. (2022)
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  • Journal Title: J Clin Med Volume: 11 Pages: 2079
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• [Journal Article] Risk Factors for Nephrotoxicity due to Tacrolimus Therapy for Ulcerative Colitis (2022)
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  • Journal Title: Digestion Volume: 103 Pages: 339-346
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• [Journal Article] The Relevance in the Neutrophil to Lymphocyte Ratio and the SARC-F Score in Gastrointestinal Diseases (2022)
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• [Journal Article] CD34+CD10+CD19- Cells in Patients with Unhealthy Alcohol Use Stimulate the M2b Monocyte Polarization (2022)
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• [Journal Article] The Relationship between the SARC-F Score and the Controlling Nutritional Status Score in Gastrointestinal Diseases (2022)
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  • Journal Title: In Vivo Volume: 36 Pages: 2780-2789
  • Peer Reviewed
• [Journal Article] Clinical Importance of Body Composition in Improving Bone Mineral Density of Femoral Neck After Denosumab Therapy in Patients With Rheumatoid Arthritis or Collagen Diseases (2022)
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• [Journal Article] Effect of an Electronic Alert System on Hepatitis B Virus Reactivation in Patients Receiving Immunosuppressive Drug Therapy (2022)
  • Author(s): Asai A, Hirai S, Yokohama K, Nishikawa T, Nishikawa H, Higuchi K
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• [Journal Article] Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique (2022)
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• [Journal Article] Therapeutic Drug Monitoring of Golimumab for the Prediction of Long-Term Clinical Remission in Patients with Ulcerative Colitis (2022)
  • Author(s): Tawa H, Kakimoto K, Numa K, Kinoshita N, Kawasaki Y, Tatsumi Y, Koshiba R, Nakata S, Hirata Y, Ota K, Sakiyama N, Kojima Y, Koubayashi E, Nishikawa H, Takeuchi T, Inoue T, Fukunishi S, Miyazaki T, Nakamura S, Higuchi K
  • Journal Title: Digestion Volume: 103 Pages: 329-338
  • Peer Reviewed
• [Journal Article] Prognostic Impact of Ectopic Fat Deposition within Psoas Muscle in Stage IV Gastric Cancer Patients Undergoing Systemic Chemotherapy (2022)
  • Author(s): Ikegami T, Nishikawa H, Goto M, Shimamoto F, Terazawa T, Yamaguchi T, Yamasaki E, Asaishi K, Nakamura S, Higuchi K
  • Journal Title: J Cancer Volume: 13 Pages: 3477-3484
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• [Journal Article] Can Lemborexant for Insomnia Prevent Delirium in High-Risk Patients with Pancreato-Biliary Disease after Endoscopic Procedures under Deep Sedation? (2022)
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  • Journal Title: J Clin Med Volume: 12 Pages: 297
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• [Journal Article] Birth weight was associated positively with gluteofemoral fat mass and inversely with 2-h postglucose insulin concentrations, a marker of insulin resistance, in young normal-weight Japanese women (2022)
  • Author(s): Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Megumu Yano, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: Diabetol Int Volume: 13 Pages: 375-380
  • DOI: 10.1007/s13340-021-00543-0
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• [Journal Article] Positive Correlation Between Changes in Serum Albumin Levels and Breakfast Non-Protein Calorie/Nitrogen Ratio in Geriatric Patients (2022)
  • Author(s): Yasuko Fukuda, Mikako Ochi, Ryouko Kanazawa, Hiromu Nakajima, Keisuke Fukuo, Masanobu Nakai
  • Journal Title: J Clin Med Res Volume: 15 Pages: 109-115
  • DOI: 10.14740/jocmr4848PMCID: PMC9990721
  • Peer Reviewed / Open Access
• [Journal Article] Influence of the nutritional status on facial morphology in young Japanese women (2022)
  • Author(s): Chihiro Tanikawa, Miki Kurata, Noriko Tanizaki, Mika Takeuchi, Edlira Zere, Keisuke Fukuo, Kenji Takada
  • Journal Title: Sci Rep Volume: 12 Pages: 18557
  • DOI: 10.1038/s41598-022-21919-5
  • Peer Reviewed / Open Access
• [Journal Article] Reduced gluteofemoral (subcutaneous) fat mass in young Japanese women with family history of type 2 diabetes: an exploratory analysis (2022)
  • Author(s): Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: Sci Rep Volume: 12 Pages: 12579
  • DOI: 10.1038/s41598-022-16890-0
  • Peer Reviewed / Open Access
• [Journal Article] Higher fasting glucose, triglycerides, resting pulse rate and high-sensitivity C reactive protein in adipose insulin-resistant but normal weight young Japanese women (2022)
  • Author(s): Satomi Minato-Inokawa, Mari Honda, Ayaka Tsuboi-Kaji, Mika Takeuchi, Kaori Kitaoka, Akiko Takenouchi, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: BMJ Open Diabetes Res Care Volume: 10 Pages: e003013
  • DOI: 10.1136/bmjdrc-2022-003013
  • Peer Reviewed / Open Access
• [Journal Article] Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fat (2022)
  • Author(s): Satomi Minato-Inokawa, Asami Hashiguchi, Mari Honda, Ayaka Tsuboi-Kaji, Mika Takeuchi, Kaori Kitaoka, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: BMJ Open Diabetes Res Care Volume: 10 Pages: e003045
  • DOI: 10.1136/bmjdrc-2022-003045
  • Peer Reviewed / Open Access
• [Journal Article] Associations of Infant Feeding with Body Composition and Cardiometabolic Health in Young Female University Students (2022)
  • Author(s): Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Miki Kurata, Tomofumi Takayoshi, Yushi Hirota, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: J Womens Health Volume: 31 Pages: 1358-1363
  • DOI: 10.1089/jwh.2021.0464
  • Peer Reviewed / Open Access
• [Journal Article] Serum Orosomucoid Is Associated with Serum Adiponectin, Adipose Tissue Insulin Resistance Index, and a Family History of Type 2 Diabetes in Young Normal Weight Japanese Women (2022)
  • Author(s): Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Miki Kurata, Tomofumi Takayoshi, Yushi Hirota, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: J Diabetes Res Volume: 2022 Pages: 7153238
  • DOI: 10.1155/2022/7153238
  • Peer Reviewed / Open Access
• [Journal Article] Weight Trajectory Since Birth, Current Body Composition, Dietary Intake, and Glucose Tolerance in Young Underweight Japanese Women (2022)
  • Author(s): Mika Takeuchi, Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: Womens Health Rep Volume: 3 Pages: 215-221
  • DOI: 10.1089/whr.2021.0127
  • Peer Reviewed
• [Journal Article] Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women (2022)
  • Author(s): Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Kaori Kitaoka, Mika Takeuchi, Megumu Yano, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: Diabetol Int Volume: 13 Pages: 220-225
  • DOI: 10.1007/s13340-021-00525-2
  • Peer Reviewed / Open Access
• [Journal Article] Social contact impacts physical activity and sedentary behavior among older adults in Japan due to COVID-19 (2022)
  • Author(s): Naoto Otaki, Miyuki Yokoro, Megumu Yano, Tomomi Imamura, Michiko Akita, Norikazu Tanino, Keisuke Fukuo
  • Journal Title: BMC Geriatr Volume: 22 Pages: 491
  • DOI: 10.1186/s12877-022-03188-z
  • Peer Reviewed / Open Access
• [Journal Article] 薬剤性小腸粘膜障害の診断におけるバルーン内視鏡とカプセル内視鏡の役割 (2022)
  • Author(s): 菅原 徳瑛(大阪医科薬科大学 第二内科), 太田 和寛, 森 洋介, 田中 宏典, 箱田 明俊, 岩坪 太郎, 平田 有基, 能田 貞治, 柿本 一城, 竹内 利寿, 樋口 和秀, 西川 浩樹
  • Journal Title: 消化器・肝臓内科 Volume: 12 Pages: 610-616
  • Peer Reviewed
• [Journal Article] クローン病に伴う短腸症候群への対応・治療法はどのようなものがあるのか (2022)
  • Author(s): 中村 志郎(大阪医科薬科大学 第二内科), 宮嵜 孝子, 柿本 一城, 平田 有基, 碕山 直邦, 小柴 良司, 峠 英樹, 中沢 啓, 川崎 裕香, 木下 直彦, 沼 圭次朗, 清水 光, 西田 光志, 西川 浩樹
  • Journal Title: 消化器・肝臓内科 Volume: 12 Pages: 442-450
  • Peer Reviewed
• [Journal Article] 非中毒性巨大結腸症を呈した大腸型Crohn病の1例 (2022)
  • Author(s): 佐野村 誠(北摂総合病院 消化器内科), 坂口 奈々子, 疋田 千晶, 辻 沙也佳, 内海 麻衣, 冨永 真央, 西川 知宏, 碕山 直邦, 西谷 仁, 柿本 一城, 中村 志郎, 西川 浩樹
  • Journal Title: 胃と腸 Volume: 57 Pages: 1490-1493
  • Peer Reviewed
• [Journal Article] 【潰瘍性大腸炎内科診療の新時代】基本治療薬と投与上の注意点 (2022)
  • Author(s): 中村 志郎, 宮嵜 孝子, 柿本 一城, 平田 有基, 碕山 直邦, 小柴 良司, 峠 英樹, 中沢 啓, 川崎 裕香, 木下 直彦, 沼 圭次朗, 山口 亮介, 清水 光, 西田 光志, 西川 浩樹
  • Journal Title: 医学と薬学 Volume: 79 Pages: 1469-1477
• [Journal Article] 肝細胞癌との鑑別診断に苦慮した肝内脾症の一例 (2022)
  • Author(s): 杉島 涼音, 大濱 日出子, 西川 浩樹, 安岡 秀高, 横濱 桂介, 後 昴佑, 松井 將太, 西川 知宏, 土本 雄亮, 朝井 章, 福西 新弥, 津田 泰宏, 樋口 和秀
  • Journal Title: 肝臓 Volume: 63 Pages: 456-462
  • Peer Reviewed
• [Journal Article] 臨床上肝原発と考えられたgerminal center B-cell-like typeのびまん性大細胞型B細胞リンパ腫の一例 (2022)
  • Author(s): 大濱 日出子(大阪医科薬科大学 第2内科), 西川 浩樹, 後 昴佑, 松井 將太, 西川 知宏, 中村 憲, 横濱 桂介, 土本 雄亮, 朝井 章, 福西 新弥, 竹下 篤, 津田 泰宏, 樋口 和秀
  • Journal Title: 肝臓 Volume: 63 Pages: 381-387
  • Peer Reviewed
• [Journal Article] 概論 JSHサルコペニア判定基準第2版 判定基準改訂の経緯と解説 (2022)
  • Author(s): 西川 浩樹
  • Journal Title: 肝胆膵 Volume: 85 Pages: 137-144
• [Journal Article] 高齢者肝硬変診療ガイドライン(解説) (2022)
  • Author(s): 名越 澄子, 赤羽 たけみ, 小木曽 智美, 坂牧 僚, 徳本 良雄, 華井 竜徳, 西口 修平, 小川 浩司, 川口 巧, 神田 達郎, 西川 浩樹, 波多野 悦朗
  • Journal Title: 日本高齢消化器病学会誌 Volume: Supplement Pages: 1-55
• [Journal Article] 消化器疾患におけるSARC-F質問票を用いた後方視的比較検討 (2022)
  • Author(s): 松井 將太(大阪医科薬科大学 内科学第II), 西川 浩樹, 後 昴佑, 小倉 健, 竹内 利寿, 後藤 昌弘, 中村 志郎, 柿本 一城, 宮嵜 孝子, 安岡 秀高, 横濱 桂介, 大濱 日出子, 朝井 章, 福西 新弥, 樋口 和秀
  • Journal Title: 日本高齢消化器病学会誌 Volume: 24 Pages: 108-114
  • Peer Reviewed
• [Journal Article] 小学校高学年の児童の生きる力と家庭及び学校における食行動・態度との関連 (2022)
  • Author(s): 脇本景子, 横路三有紀, 大倉健太郎, 岸田恵津
  • Journal Title: 健康教育学会誌 Volume: 30 Pages: 283-292
  • Peer Reviewed
• [Presentation] Non-heat-stressed method to isolate hepatic stellate cells from highly steatotic tumor-bearing liver usingCD49a (2023)
  • Author(s): Yi Cheng, Ryota Yamagishi, Yoshiki Nonaka, Misako Sato-Matsubara, Norifumi Kawada, and Naoko Ohtan
  • Organizer: The 32nd Conference of the Asian Pacific Association Study of the Liver(APASL2023)
• [Presentation] 腸内細菌叢と肥満関連肝がん; ～Leaky gutによる腸内細菌関連物質の肝移行の関与～ (2022)
  • Author(s): 大谷直子
  • Organizer: 第26回腸内細菌学会学術集会 シンポジウム2：マイクロバイオームの制御と健康
• [Presentation] 肥満と肝がん;腸内細菌叢成分による肝がん促進的微小環境の形成 (2022)
  • Author(s): 大谷直子
  • Organizer: 第8回がんと代謝研究会 in 佐渡
• [Presentation] ガレクチン３による骨格筋内異所性脂肪の形成促進; ～シングルセル解析を利用した分化異常の検出～ (2022)
  • Author(s): 大谷直子
  • Organizer: 第8回日本筋学会学術集会 シンポジウム7：健康長寿の実現に向けたサルコペニア／フレイル研究の新展開
• [Presentation] 肥満による肝がんの進展メカニズム ～腸内細菌関連因子の関与～ (2022)
  • Author(s): 大谷直子
  • Organizer: 第2回バイオインダストリー協会 機能性食品研究会講演会
• [Presentation] Hepatic transfer of gut microbial component promotes obesity-associated liver cancer progression (2022)
  • Author(s): Naoko Ohtani
  • Organizer: 日本学術振興会主催の第23回北東アジアシンポジウム（テーマ：細胞老化）
  • Int'l Joint Research / Invited
• [Presentation] The role of hepatic stellate cells in tumor microenvironment of obesity-associated liver cancer (2022)
  • Author(s): Naoko Ohtani
  • Organizer: The 2nd Osaka Metropolitan University International Liver Forum
  • Int'l Joint Research / Invited
• [Presentation] Hepatic transfer of gut microbial component promotes obesity-associated liver cancer progression (2022)
  • Author(s): Naoko Ohtani
  • Organizer: 第81回日本癌学会学術総会Symposium 5 Metabolic alteration in the Tumor microenvironment
• [Presentation] 細胞老化とＳＡＳＰ：その誘導機構とがん微小環境における役割 (2022)
  • Author(s): 大谷直子
  • Organizer: 第48回日本臓器保存生物医学会学術集会
  • Invited
• [Presentation] Obesity-associated liver cancer: the role of hepatic translocation of gut microbial factors (2022)
  • Author(s): Naoko Ohtani
  • Organizer: IHMC KOBE 2022 The International Human Microbiome Consortium Congress
  • Int'l Joint Research / Invited
• [Presentation] The role and mechanism of SASP in tumor microenvironment of obesity-associated liver cancer (2022)
  • Author(s): Naoko Ohtani
  • Organizer: The 12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research: Translating Knowledge into Practice
  • Int'l Joint Research / Invited
• [Presentation] 肥満と肝がん ～腸内細菌関連物質の肝移行とがん微小環境形成～ (2022)
  • Author(s): 大谷直子
  • Organizer: 第35回 日本バイオセラピィ学会学術集会総会モーニングセミナー
  • Invited
• [Presentation] 腸内細菌叢と肥満関連肝がん～Leaky gutによる腸内細菌関連物質の肝移行の関与～ (2022)
  • Author(s): 大谷直子
  • Organizer: 第54回無菌生物ノートバイオロジー学会 シンポジウム 「常在細菌と宿主免疫の新たな展開」
  • Invited
• [Presentation] Gut-liver Axis-Mediated Mechanism of Obesity-Associated Hepatocellular Carcinoma Progression (2022)
  • Author(s): Naoko Ohtani
  • Organizer: Asian Pacific Association for the Study of the Liver (APASL) 2023
  • Int'l Joint Research / Invited
• [Presentation] Intestinal microbiome and liver cancer (2022)
  • Author(s): Naoko Ohtani
  • Organizer: USJCMSP 2023 International Conference on Emerging Infectious Diseases Cancer Panel
  • Int'l Joint Research / Invited
• [Presentation] 比較生物学的アプローチから示される加齢にともなう遺伝子発現変化とその生体における有益性 (2022)
  • Author(s): 吉田優矢、高杉征樹、野中允幾、大谷直子
  • Organizer: NGS EXPO 2022
• [Presentation] 加齢にともなう遺伝子発現変化は長寿の指標として有益なものである：比較生物学的アプローチより (2022)
  • Author(s): 吉田優矢、高杉征樹、野中允幾、大谷直子
  • Organizer: 第45回日本分子生物学会年会
• [Presentation] IL-33によるNASH関連肝がん促進機構 (2022)
  • Author(s): 山岸良多、武藤芳美、河田則文、大谷直子
  • Organizer: 第59回日本肝臓学会総会
• [Presentation] IL-33released from senescent hepatic stellate cell promotes obesity-associated hepatocellular carcinoma (2022)
  • Author(s): Ryota Yamagishi, Fumitaka Kamachi, Tomonori Kamiya, Yi Cheng, Yoshiki Nonaka, Norifumi Kawada, Susumu Nakae, Eiji Hara, Naoko Ohtani
  • Organizer: APASL Oncology 2022 Single Topic conference in Takamatsu
• [Presentation] IL-33released from senescent hepatic stellate cell promotes obesity-associated hepatocellular carcinoma (2022)
  • Author(s): Ryota Yamagishi, Fumitaka Kamachi, Yi Cheng, Norifumi Kawada, Eiji Hara, Naoko Ohtani
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] がん微小環境における細胞老化とSASPの役割：ガスダーミンDを介するSASP因子の放出が肥満関連肝がんを促進させる (2022)
  • Author(s): 山岸良多、蒲池史卓、神谷知憲、高杉征樹、程禕、野中允幾、河田則文、中江進、原英二、大谷直子
  • Organizer: 日本生理学会第100回記念大会
• [Presentation] Regular exercise suppresses obesity associated liver cancer through activating Pgc-1α-Kynurenine degrading pathway (2022)
  • Author(s): Vu Thuong Huyen, Ryota Yamagishi, Naoko Ohtani
  • Organizer: APASL Oncology 2022 Single Topic conference in Takamatsu
• [Presentation] Regular exercise suppresses obesity associated liver cancer through activating Pgc-1α-Kynurenine degrading pathway (2022)
  • Author(s): Vu Thuong Huyen, Ryota Yamagishi, Naoko Ohtani
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] 肥満誘導性肝がん微小環境における腫瘍促進ネットワークの複合バイオインフォマティクス解析 (2022)
  • Author(s): 野中允幾、山岸良多、程禕、大谷直子
  • Organizer: 第81回日本癌学会学術総会(横浜）
• [Presentation] Combined Bioinformatics on the Tumor Promoting Inter-cellular Network in Obesity-associated Liver Tumor Microenvironment (2022)
  • Author(s): Yoshiki Nonaka, Ryota Yamagishi, Yi Cheng, Naoko Ohtani
  • Organizer: APASL Oncology 2022 Single Topic conference in Takamatsu
• [Presentation] 肥満誘導性肝がん微小環境における腫瘍促進ネットワークの複合解析 (2022)
  • Author(s): 野中允幾、山岸良多、程禕、小玉尚宏、大谷直子
  • Organizer: NGS EXPO 2022
• [Presentation] 肝性脳症発症に関わる腸内細菌の同定 (2022)
  • Author(s): 神谷知憲，武藤芳美，藤井英樹，森宙史，豊田敦，福田真嗣，河田則文，大谷直子
  • Organizer: 第26回腸内細菌学会学術集会
• [Presentation] Non-heat-stressed method to isolate hepatic stellate cells from highly steatotic tumor-bearing liver usingCD49a (2022)
  • Author(s): Yi Cheng, Ryota Yamagishi, Yoshiki Nonaka, Misako Sato-Matsubara, Norifumi Kawada, and Naoko Ohtani
  • Organizer: THE LIVER SINUSOID MEETING,21st ISCHS Meeting
• [Presentation] Identification and characterization of the gut microbial species responsible for hyperammonemia in hepatic encephalopathy from the analysis of patients administered rifaximin (2022)
  • Author(s): Yoshimi Yukawa-Muto, Tomonori Kamiya, Norifumi Kawada, Naoko Ohtani
  • Organizer: IHMC KOBE 2022～The International Human Microbiome Consortium Congress～
• [Presentation] Rifaximin治療効果に基づく肝性脳症原因菌の同定とメカニズムの解明 (2022)
  • Author(s): 武藤（湯川）芳美，河田則文，大谷直子
  • Organizer: 日本消化器関連学会週間（JDDW）ワークショップ「消化器疾患とマイクロバイオーム研究の新展開」
• [Presentation] 肝性脳症における腸内細菌叢ーリファキリミン非著効例における菌種の機能解析ー (2022)
  • Author(s): 武藤芳美，河田則文，大谷直子
  • Organizer: 第108回日本消化器病学会総会 ワークショップ1
• [Presentation] 肝性脳症発症に関わる腸内細菌の探索 (2022)
  • Author(s): 武藤芳美、神谷知憲、小田桐直志、小谷晃平、元山宏行、川村悦史、萩原淳司、藤井英樹、打田佐和子、榎本大、河田則文、大谷直子
  • Organizer: 第29回日本門脈圧亢進症学会総会 パネルディスカッション3
• [Presentation] Hepatoma-derived growth factor (HDGF) の肝癌増殖における役割の検討 (2022)
  • Author(s): 榎本平之、中村秀次、飯島 尋子
  • Organizer: 第108回 日本消化器病学会総会ワークショップ10:肝疾患の遺伝子解析による病態解明と臨床展開
• [Presentation] HBV感染者の線維化と発がんにおける生活習慣関連因子の関連についての検討 (2022)
  • Author(s): 榎本平之、会澤信弘、飯島 尋子
  • Organizer: 第58回日本肝臓学会総会シンポジウム1: ウイルス性肝疾患の完全克服とマネジメント
• [Presentation] 肝硬変の生活の質に関する検討：サルコペニアとの関連について (2022)
  • Author(s): 榎本平之、楊和典、飯島 尋子
  • Organizer: 第26回日本肝臓学会大会シンポジウム 5：肝硬変診療ガイドライン改訂後の診療と研究
• [Presentation] A high expression of SHROOM4 was associated with a favorable prognosis in HCC patients (2022)
  • Author(s): Enomoto H., Nishimura T., Aizawa N., Takashima T., Ikeda N., Yuri Y., Okamoto M., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Iijima H
  • Organizer: APASL Oncology 2022
  • Int'l Joint Research
• [Presentation] Etiological transitions in patients with liver cirrhosis and hepatocellular carcinoma: a single-center study from an institution located in a district with a high prevalence of viral hepatitis (2022)
  • Author(s): Enomoto H., Takashima T., Nishimura T., Aizawa N., Ikeda N., Yuri Y., Okamoto M., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Iijima H
  • Organizer: APASL Oncology 2022
  • Int'l Joint Research
• [Presentation] Hepatoma-derived growth factor as a potential target molecule for the treatment of hepatocellular carcinoma (2022)
  • Author(s): Enomoto H
  • Organizer: The Asian Pacific Association for the Study of the Liver Single Topic Conference
  • Int'l Joint Research
• [Presentation] Induction of the SHROOM4 gene as a possible negative feedback response to hepatoma-derived growth factor (2022)
  • Author(s): Enomoto H., Aizawa N., Takashima T., Ikeda N., Yuri Y., Okamoto M., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Nishimura T., Iijima H
  • Organizer: The 73rd Annual Meeting of the American Association for the Study of Liver Diseases
  • Int'l Joint Research
• [Presentation] Correlation of Renal Function and Muscle Mass in Young Athletes (2022)
  • Author(s): Osamu Yasuda, Hisayo Yasuda, Mitsuru Ohishi
  • Organizer: International Society of Hypertension
  • Int'l Joint Research
• [Book] Recent Advances in the Diagnosis and Treatment of Chronic Liver Diseases (2022)
  • Author(s): Enomoto H
  • Total Pages: 112
  • Publisher: MDPI Open Access Books
  • ISBN: 978-3-0365-2993-6