Function of cerebellar nucleus in motor learning

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K06448
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 46030:Function of nervous system-related
• Research Institution: National Institute of Information and Communications Technology (2022-2023); Osaka University (2021)
• Principal Investigator: Masato Inoue 国立研究開発法人情報通信研究機構, 未来ICT研究所脳情報通信融合研究センター, 主任研究員 (10423047)
• Co-Investigator(Kenkyū-buntansha): 北澤 茂 大阪大学, 大学院生命機能研究科, 教授 (00251231)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 運動学習 / サル / リーチング / ニューロン活動 / 小脳

Outline of Final Research Achievements

Due to the sudden death of the trained monkeys, recording was no longer possible, but by training another monkey, recording could begin in March 2024. Although the period was too short to obtain sufficient data for analysis, results are now being obtained that suggest that neurons in the cerebellar nuclei encode error information.
This study was conducted in collaboration with a co-researcher, Professor Shigeru Kitazawa of the Graduate School of Frontier Biosciences, Osaka University. Animal experiments in this study were conducted in accordance with the "Basic Guidelines for the Proper Conduct of Animal Experiments" established by the Science Council of Japan. This study was conducted with the approval of the Ethical Review Committee for Animal Experiments of the Graduate School of Frontier Biosciences, Osaka University.

Free Research Field

神経生理学

Academic Significance and Societal Importance of the Research Achievements

この研究により、運動の誤差情報処理への小脳のLTDの関与を明らかにすることができ、大脳皮質のLTPと小脳のLTDの運動学習へ役割の違いを明らかにすることが出来ると考えられる。この研究により、大脳皮質と小脳への効果的な刺激方法を開発する事により、効果的なリハビリテーション法や運動の訓練方法の確立に寄与できると考えられる。