2023 Fiscal Year Final Research Report
Are T cells present restricted to the HLA not shared with patient and donor in HLA-mismatched transnplantation??
| Project/Area Number |
21K08408
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54010:Hematology and medical oncology-related
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤原 弘 三重大学, 医学系研究科, 産学官連携講座教授 (20398291)
福永 景子 兵庫医科大学, 医学部, 助教 (60649185)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | HLA不適合移植 / HLA拘束性 |
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| Outline of Final Research Achievements |
After HLA-mismatched transplantation, donor T cells are restricted to either shared HLA, donor-specific HLA, or host-specific HLA. In this study, we examined HLA restriction using HLA-A24 and A02-restricted CMV tetramers in 64 samples from 40 cases. Beyond 900 days post-transplantation, all cases showed the presence of shared HLA-restricted T cells. Host-specific HLA-restricted T cells were not detected, while donor-specific HLA-restricted T cells were found in half of the patients after 90 days. Based on transplant types, shared HLA and donor-specific HLA-restricted T cells tested positive in 50% and 57% of HLA-haploidentical transplants, 75% and 67% of 2-haplotype-mismatched transplants, and 67% and not applicable in spousal transplants, respectively.
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| Free Research Field |
造血細胞移植
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| Academic Significance and Societal Importance of the Research Achievements |
共有HLA拘束性T細胞の存在はHLA半合致移植後の宿主防御を説明し、ドナー特異的HLA拘束性T細胞の存在は、血球向性ウイルスに対する宿主防御を説明し、宿主特異的HLA拘束性T細胞の存在は、上皮向性ウイルスに対する宿主防御を説明する。本研究ではHLA半合致の条件を越えた移植においても、共有HLAおよびドナー特異的HLA拘束性T細胞の存在は確認されたが、宿主特異的HLA拘束性T細胞は検出されなかった。にもかかわらず、HLAがすべて異なるドナーから移植した一例では、上皮向性ウイルスであるCOVID19が治癒した経験がある。現在、これらの結果をまとめた論文を投稿し、リバイス中である。
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